PASTEUR EFFECT 71 



"resting" organisms only part of the disappearing non-nitrogenous 

 metabolite could be accounted for by oxidation, while a large part 

 was converted into cell material, presumably carbohydrate. This 

 conversion was completely interrupted in the presence of dinitro- 

 phenol, in which case catabolic breakdown continued until all ma- 

 terial was oxidized (78, 79). 



Dinitrophenol has therefore become an important tool for the 

 study of the relation between anabolic and catabolic processes, 

 which must be determined by the flow of energy-carrying reactions. 

 In a recent paper (3) where I have discussed the generation and 

 transfer of energy-rich phosphate bonds it is stated that a major 

 part of metabolically yielded energy is converted primarily into 

 phosphate bond energy. An understanding of the means by which 

 the cell directs the flow of energy-rich phosphate bonds into pre- 

 determined reactions should lead to a more precise understanding 

 of the mechanism of regulative cell reactions such as the Pasteur 

 effect and the probable related action of the hormones. 



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