238 



A SYMPOSIUM ON RESPIRATORY ENZYMES 



(presumably 1-8-12, if corrected to initial dry weights). These 

 results for normal liver, with the possible exception of some very 

 early work of Rosenthal ( 14), are practically unique in the literature 

 of liver metabolism. In our own experiments, Nakatani et ah, and (so 

 far as I know) essentially all others, anaerobic glycolysis Q values 

 of more than 2 (initial dry weight basis) have never been consistently 

 reported. In our experience with many hundreds of normal rat livers 

 under a great variety of dietary conditions, Q^^a values of 1 or 

 considerably less were regularly obtained in rats weighing over 50 

 grams (using the ordinary manometric methods, and with varying 

 periods of oxygenation between the killing of the rat and the estab- 

 lishment of anaerobiosis). Without attempting to account at this 



Table 1.— A comparison of the metabolism* of various rat liver 



tumors with various homologous liver tissues (normal, 



embryonic, aged, cirrhotic, regenerating) 



* Q values based on initial dry weights (original data of Tamiya (16) based on final 

 dry weights and here factored by 50 per cent to reduce to approximate initial dry 

 weight; cf. refs 5 and 8c).Qoj,Q'^2AandQ°2^ = inm.' oxygen consumption, anaerobic and 

 aerobic acid production/mg. initial dry weight of tissue per hr.; R.Q. = respiratory 

 quotient = Qo2/Qc02; M.O.Q. = Meyerhof oxidation quotient = 3(QN2A.— Q°2a)/Qoj; 

 tJ = fermentation excess = Q'^'^a — 2Q02. 



t Sample of average data taken with O. K. Behrens and K. Sugiura (cf. ref. 4 et seq.). 

 Up to 30 specimens of each tissue type examined metabolically. Rats fed 0.06 per cent 

 p-dimethylaminoazobenzene (butter yellow) for 150-200 days on brown rice-carrot 

 diet. "Yeast-protected" with 5-15 per cent added dried brewer's yeast. 



J 33d generation, subcutaneously transplanted, o-aminoazotoluene-induced liver 

 carcinoma 1 in dba strain. Mouse obtained from Dr. H. B. Andervont through Dr 

 P. M. West; liver of same animal: QN'a = 0.8; QO2a = 1.0. 



