DISCUSSION ON TUMOR RESPIRATION 245 



parative biochemistry, not intermediate metabolism. The studies 

 made in recent years by Elhott and by Potter, and especially this 

 year by Salter and collaborators (15), on the deficient (cytochrome- 

 succinate) oxidation systems in many tumors as compared with 

 tissues of varying degrees of homologousness, will undoubtedly lead 

 the way in indicating by what mechanisms, if any, the respiration 

 systems of tumors permit high glycolysis to occur. But that is a 

 story for the future. The paper of Mr. Kensler now to follow, based 

 on his study with Dr. C. P. Rhoads (9a) on the action of butter 

 yellow intermediates (free radicals) in correlating metaboHsm and 

 carcinogenic action, will present an exceedingly promising pioneer 

 work that opens up an entirely new approach to the connection be- 

 tween tumor metabolism and tumor genesis, an approach that will, 

 I believe, command the admiration of us all. 



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