THE CYTOPLASM 223 



derived from studies on "cyclophorase"^^ are not warranted, on the other 

 hand, because of the cytological heterogeneity of cyclophorase and because 

 most of the conclusions relating to cytochemistry were based on oxygen 

 uptake measurements without reference to the whole tissue^ '^'^'^ (cf. the 

 oxidation of D-isocitrate (Table I)). 



« W. C. Schneider and G. H. Hogeboom, J. Xatl. Cancer Inst. 10, 969 (1950). 

 3« G. H. Hogeboom, A. Claude, and R. D. Hotchkiss, J. Biol. Chem. 165, 615 (1946). 

 " W. C. Schneider, J. Biol. Chem. 165, 585 (1946). 



98 G. H. Hogeboom and W. C. Schneider, J. Natl. Cancer Inst. 10, 983 (1950). 

 35 G. H. Hogeboom, /. Biol. Chem. 177, 847 (1949). 

 o» P. Siekevitz, /. Biol. Chem. 195, 549 (1952). 



»' E. P. Kennedy and A. L. Lehninger, J. Biol. Chem. 179, 957 (1949). 

 02 W. C. Schneider and V. R. Potter, J. Biol. Chem. 177, 893 (1949). 

 «3 W. C. Schneider, J. Biol. Chem. 176, 259 (1948). 

 "^ W. W. Kielley and R. K. Kielley, /. Biol. Chem. 191, 485 (1951). 

 "s J. H. Copenhaver, and H. A. Lardy, J. Biol. Chem. 195, 225 (1952). 

 »6A. L. Lehninger, J. Biol. Chem. 190, 345 (1951). 



<" A. L. Lehninger, in "Phosphorus Metabolism," (McElroy and Glass, eds.). Vol. 

 1, p. 344. Johns Hopkins Press, Baltimore, 1951. 



08 A. F. Muller and F. Leuthardt, Helv. Chim. Acta 32, 2349 (1949). 



09 V. R. Potter, G. G. Lyle, and W. C. Schneider, J. Biol. Chem. 190, 293 (1951). 



10 P. Siekevitz and V. R. Potter, J. Biol. Chem. 200, 187 (1953). 

 " E. L. Kuff, J. Biol. Chem. 207, 361 (1954). 



12 C. J. Kensler, and H. Langemann, J. Biol. Chem. 192, 551 (1951). 

 '3 J. N. Williams, /. Biol. Chem. 194, 139 (1952). 



4 J. N. Williams, J. Biol. Chem. 195, 37 (1952). 



5 G. C. Cotzias and V. P. Dole, Proc. Soc. Exptl. Biol. Med. 78, 157 (1951). 



6 J. Hawkins, Biochem. J. 50, 577 (1952). 



' S. Ludewig and A. Chanutin, Arch. Biochem. 29, 441 (1950). 

 '8 H. von Euler and L. Heller, Z. Krebsforsch. 56, 393 (1949). 



19 W. C. Schneider and G. H. Hogeboom, J. Biol. Chem. 195, 161 (1952). 



20 A. H. Schein, E. Podber, and A. B. Novikoff, J. Biol. Chem. 190, 331 (1951). 



21 B. H. Sorbo, Acta Chem. Scand. 5, 724 (1951). 



22 M. E. Maver and A. E. Greco, J. Natl. Cancer Inst. 12, 37 (1951). 



23 J. A. Shepherd and G. Kalnitsky, J. Biol. Chem. 192, 1 (1951). 

 2^ J. Berthet and C. de Duve, Biochem. J. 50, 174 (1951). 



25 G. E. Palade, Arch. Biochem. and Biophys. 30, 144 (1951). 



26 A. F. Muller and F. Leuthardt, Helv. Chim. Acta 33, 268 (1950). 



27 R. K. Kielley and W. C. Schneider, J. Biol. Chem. 185, 869 (1950). 



28 J. M. Price, E. C. Miller, and J. A. Miller, Proc. Soc. Exptl. Biol. Med. 71, 575 

 (1949). 



29 M. E. Swendseid, F. H. Bethell, and W. W. Ackermann, J. Biol. Chem. 190, 791 

 (1951). 



30 J. M. Price, E. C. Miller, and J. A. Miller, J. Biol. Chem. 173, 345 (1948). 

 30a W. C. Schneider and G. H. Hogeboom, unpublished data. 



30b H. Higgins, J. A. Miller, J. M. Price, and F. M. Strong, Proc. Soc. Exptl. Biol. 

 Med. 75, 462 (1950). 



31 W. C. Schneider, M. J. Striebich, and G. H. Hogeboom, unpublished data. 



32 M. A. Swanson and C. Artom, J. Biol. Chem. 187, 281 (1950). 



