396 



R. M. S. SMELLIE 



TABLE 1 



The Relative Uptakes of P'^ by the DNA of Different Tissues 



Expressed as a Ratio Relative to the Value for the Spleen in 



Each Group as 10 



Species 



Tissue 



Time after 



administration, 



hr. 



Relative 

 uptake 



Ref. 



Rat 



Spleen 



Intestine 



Testes 



Muscle 



Liver 



Kidney 



Brain 



94 



10.0 

 22.9 

 1.4 

 2.0 

 2.3 

 1.1 

 0.3 



Rat 



Spleen 



Intestine 



Liver 



10.0 



13.2 



0.5 



Rat Spleen 



Bone marrow 



Thymus 



Intestinal lymph nodes 



Skin lymph nodes 



10.0 

 185.7 

 85.7 

 18.6 

 18.6 



Mouse 



Spleen 



Intestine 



Liver 



10.0 

 5.5 

 0.3 



10 



Rabbit Spleen 



Appendix 



Bone marrow 



Thymus 



Intestinal mucosa 



Liver 



Kidney 



Brain 



18 



10.0 



96.5 



82.2 



35.2 



30.8 



3.0 



2.0 



1.0 



11 



Similarly, the rate of renewal of weanling rat liver DNA is high in compari- 

 son with the normal. It has been shown^''""'^'^^ that the presence of a 



»3 S. Albert, R. M. Johnson, and M. S. Cohan, Cancer Research 11, 772 (1951). 



1^ L. S. Kelly, A. H. Payne, M. R. White, and H. B. Jones, Cancer Research 11, 694 



(1951). 

 's A. C. Griffin, L. Cunningham, E. L. Brandt, and D. W. Kupke, Cancer 4, 410 (1951) . 

 '« E. P. Tyner, C. Heidelberger, and G. A. LePage, Cancer Research 13, 186 (1953). 

 " W. M. Mclndoe and J. N. Davidson, Brit. J. Cancer 6, 200 (1952). 

 18 A. H. Payne, L. S. Kelly, and M. R. White, Cancer Research 12, 65 (1952). 



