PREFACE XI 



This first volume will l)e concerned with the general principles of enzyme 

 inhibition and specific inhibitors will be mentioned only for illustration of 

 these principles. The second and third volumes will deal with the individual 

 inhibitors and inhibitor groups, and there much that is discussed in the 

 present volume will be applied. 



Inasmuch as the Preface is the only place in a book where one can attend 

 to personal questions, one may perhaps be anticipated. Some may justifiably 

 question my qualifications for writing on such a subject and for so often 

 suggesting the ways in which inhibition studies be done. I can only answer 

 this by saying that I believe I realize my inadequacies more keenly than the 

 reader does, having lived with them daily, but desire to contribute a little 

 to the formulation of this field of inhibition, and perhaps stimulate others 

 to more penetrating analyses and to better presentations in the future. 



I would here like to express my gratitude to Professor Linus Pauling 

 for perusing the manuscript and writing the Foreword, and also for what 

 he has contributed to my imderstanding in the past. 



J. Leyden AVebb 



Department of Pharmacology 



School of Medicine 



University of Southern California 



January, 1963 



