SYMBOLS 



dg equilibrium distance between 



interacting particles 

 do thermal equilibrium distance 



between interacting particles 

 D dielectric constant 



e electronic charge (4.802 x 10^'° 



esu) 

 E enzyme (often apoenzyme) 



Eq catalytically active enzyme 



Fact Arrhenius activation energy 

 Erf catalytically inactive enzyme 



(denatured) 

 E( total enzyme 



EA enzyme-activator complex 



EH protonated enzyme (active site ) 

 EI enzyme-inhibitor complex 



EP enzyme-product complex 



ES enzyme-substrate complex 



EX* activated complex of enzyme 



with substance X 

 / force exerted on charged par- 



ticle in electric field 



mean fractional inhibition 



inhibition required for lethal 



action 



inhibitor 



inhibitor inside a compartment 



I„ inhibitor outside a compart- 



ment 



/j, [2 ionization potentials 



(I ) i lethal concentration 



(I),„ minimal inhibitor concentra- 

 tion to produce effect 



(1)50 concentration for 50% inhibi- 

 tion 



k rate or permeability constant 



k Boltzmann constant (1.380 X 



l(j-i6 erg/deg-molecule) 



k„, salting coefficient 



A'„ rate constant for a particular 



step n 



k-_„ rate constant for reverse reac- 



tion of step n 



K equilibrium (dissociation) con- 



stant [= (A)(B)/(AB)] 



K„ activator constant 



K„ ionization constant 



/v„3 dissociation constant for sub- 

 strate-activator complex 



A'j inhibitor constant 



K/ experimental or apparent in- 



hibitor constant 



A','^ inhibitor constant for isoelec- 

 tric enzyme 



K„^ Michaelis constant 



Kg equilibrium constant between 



S and P 



Kj, Michaelis constant for reverse 



reaction (product reaction) 



A'r dissociation constant for in- 



hibitor-reversor complex 



A, dissociation constant for en- 



zyme-substrate complex (sub- 

 strate constant) 



K/ experimental or apparent sub- 

 strate constant 



Asi dissociation constant for sub- 



strate-inhibitor complex 



Asp equilibrium constant between 

 ES and EP 



I length of dipole 



L limiting rate coefficient 



M number of molecules of sub- 



strate or inhibitor binding to 

 an active site 



