XX 



CONTENTS 



CHAPTER 12 



Rates of Inhibition 



General Ways of Expressing the Rate of Inhibition 

 Rates of Inhibition of Pure Enzymes .... 

 Rates of Inhibition in Mitochondria, Cells, and Tissues 

 Rates of Lethal Action in a Cell Population 

 Concentration -Time Curves for Inhibition . 



535 



536 

 541 

 571 

 590 

 595 



CHAPTER 13 



Reversal of Inhibition 



Ways in Which Reversal of Inhibition May Be Achieved 

 Dissociation of the Enzyme-Inhibitor Complex . 

 Competitive Displacement of the Inhibitor by Substrate 

 Reversal of Inhibition by a Substance Binding the Inhibitor 

 Spontaneous Reactivation of Inhibited Enzymes 

 Induced Reactivation of Inhibited Enzymes . 

 Reversal of Inhibition by Destruction of Inhibitor . 

 Reversal of Inhibitions in Cells and Whole Animals 



605 



606 

 607 

 612 

 615 

 626 

 630 

 637 

 642 



CHAPTER 14 



Effects of pH on Enzyme Inhibition 



Expressions for the pH -Functions of W^eak Acids and Bases 



Variation of Enzyme Activity with pH 



Variation of Enzyme Inhibition with pH 



Variation of Multienzyme Inhibition with pH .... 

 Variation of Intracellular Inhibition with pH .... 



649 



650 

 652 

 667 

 711 

 713 



CHAPTER 15 



Effects of Various Factors on Inhibition 



Effects of Temperature: Enzymes 



Effects of Temperature: Multienzyme Systems . 



Effects of Temperature: Cellular Systems . 



Effects of the Dielectric Constant 



Effects of Salt Concentration and Ionic Strength 



Effects of Buffers 



Effects of Pressure 



Effects of Extraneous Binding and Impurities 

 Effects of Enzyme or Metabolic Rate 



747 



747 

 768 

 773 

 799 

 815 

 839 

 841 

 854 

 857 



CHAPTER 16 



Specificity of Inhibition 



863 



