220 



6. INTERACTIONS OF INHIBITORS WITH ENZYMES 



Table 6-2 



Properties of Biologically Important Bonds '^ 



" These are eclectic values from several recent sources. The dipole moments of 

 some bonds have been corrected for the reversal of the earlier C — H bond moment 

 (Wheland, 1955, p. 209); according to the classic direction the moments are C — N, 

 0.22; C-0, 0.74; C-Cl, 1.46; C-Br, 1.38; C-I, 1.19 (Smyth, 1955, p. 244;. 

 The atomic charge has beer calculated from the bond distance and the dipole moment 

 and is given in electron charge units. In some cases Rq has been calculated from i?^, 

 the refraction at the sodium D line. All values are subject to variation with different 

 groups on the bonded atoms. 



be important in situations in which the polarizing charge is in a fixed con- 

 figuration with respect to the molecule polarized. 



In the evaluation of the interaction energy between an ion and the in- 

 duced dipoles in a complex molecule, it is necessary to integrate the in- 

 teraction over the atoms and bonds involved. In a large molecule it is not 

 necessarily the total molar refraction that is important; in a uniform field 

 the total refraction or polarizability has significance but in the decremental 

 field of an ion it is more accurate to consider the contributions of each bond 

 or group at its distance from the ion. 



