INTERACTION FORCES IN VARIOUS ENZYME SYSTEMS 



293 



Table 6-26 

 Relative Binding Energies of Inhibitors to Carboxypeptidase " 



Inhibitors 



CHjCH^-COO" 

 CHgCHaCHj-COO" 

 CHaCHsCHjCHa-COO" 

 CH3CH2CH2CH2CH2 - COO' 

 CH,. 



)CH-CHX'H,-COO' 



CH, 



\_/^ 



/_x-coo- 



<f^^-CH2-C00' 

 ^\-CH,CH,-COO- 

 CH,CHX'H,-COO~ 



/\/ 



N^ 



%/" 



-CH,-COO" 



N^ 



\/" 



J_ 



N^ 



XX" 



CH,CH,-COO' 



CH,CH,CH,-COO' 



%_/- 



-CH^CH^ 



COO" 



//\/K 



COO 

 CHX'H,-COO~ 



-CH,-COO' 



(mi/) 



100 

 5 



2.7 

 6.25 



2.7 



143 

 4.55 

 1.2 

 20 



0.78 



5.55 



33.3 



4.0 



20 



45.5 



Relative 



binding energy 



(kcal/mole) 



-1.36 

 -3.13 

 -3.50 

 -3.00 



-3.50 



-1.15 

 -3.18 

 -3.97 

 -2.31 



-4.22 



-3.06 



-2.00 



-3.26 



2.31 



-1.82 



" Data from Smith tt al. (1951). The binding energies were calculated from the 

 values of A',. 



