620 



13. REVERSAL OF INHIBITION 



The ability of a reversor to diminish an inhibition is then related to the 

 position of the I-R curve relative to the I-E curve on the scale. Thus 

 reversor 1 (upper curve) would decrease the inhibition much more effec- 

 tively than reversor 2 (lower curve). 



pl 



(RI) 



(R) 



Fig. 13-7. Representation 

 of inhibition reversal on a pi 

 scale (Eqs. 13-29 and 13-30). 

 The reversor 1 (upper curve) 

 would decrease the inhibi- 

 tion more readily than the 

 reversor 2 (lower curve). 



Kinetics of Inhibition Reversal by Substances Binding the Inhibitor 



If it is assumed that the reversor reacts only with free inhibitor and 

 not with inhibitor bound to the enzyme, the first reaction that occurs upon 

 adding the reversor is: 



R + I 



RI 



(13-31) 



