INDUCED REACTIVATION OF INHIBITED ENZYMES 



635 



and the inhibition may be shown to be: 



\ 



(I) 



1 + 



^^^ ^ ^' I hiiDlK,] + hm 



;i3-58) 



TIME 



Fig. 13-11. Reactivation of acetylcholinesterase carbamylated by 



dimethylcarbamylcholine or diraethylcarbamyl fluoride. (From 



Wilson et al., 1960.) Curve A: spontaneous reactivation; curve 



B: reactivation with hvdroxylamine. 



which is the same as Eq. 13-47 except for the dependency on (R), the 

 concentration of the reactivator. It is assumed in this treatment that there 

 is no spontaneous reactivation 



The reactivation rate varies with (a) the enzyme that is inhibited, (6) 

 the nature of the inhibitor, (c) the nature of the reactivator, (d) the tem- 



