756 



15. EFFECTS OF VARIOUS FACTORS ON INHIBITION 



that changes in the enzyme structure predispose it to inhibition by ure- 

 thane at these temperatures and that the rapid rise in the inhibition is 

 not entirely due to an increased affinity. Below 45° the inhibition is much 

 less dependent on temperature and around 25° there appears to be no va- 



cs - 



0.5 



Fig. 1.5-4. Effects of temperature on the inhibitions of 

 catalase by fovu' inhibitors. Concentrations are given in 

 milhmohir. (From Gressly and Aebi, 19.59.) 



riation with temperature. The mechanisms involved in this inhibition will 

 be discussed in the later section on pressure effects, inasmuch as high pres- 

 sures antagonize the rise in the inhibition with temperature. 



Dependence of Rates of Inhibition on Temperature 



If the rate at which inhibition develops is related to the combination of 

 the inhibitor with the enzyme according to: 



E + I 



EI 



(15-8) 



