SPECIFICITY OF INHIBITION 



875 



Thus, if the inhibition on Ej must be 50%, (I/) = (I2') = 1, i.e., the sum 

 of the specific concentrations of the two inhibitors with respect to E^ must 

 be unity. (Ij) and (Ig) must now be chosen so that this equation is obeyed 



Table 16-2 

 Specificities of Ixhibition by Two Ixhibitors on a Three-Enzyme System " 



Inhibition on 



" The assumed values of the inhibitor constants are: A', = 0.3 \\\M, K, -^ 3 mM, 



'11 '12 



Kj = 1 mM, and K^ = 5 vall. 0^2 is the specificity with respect to E2 and 0^3 

 with respect to E3. 



