SUBJECT INDEX 



Accumulation. 



of inhibitors, during repeated adminis- 

 trations, 421-424 

 of intermediates. 



in localization of action, 513-515 

 in monolinear chains, 329. 336-337 

 reasons for failure to occur, 514 

 Acetaldehyde, 



inhibition of pjTuvate decarboxylase, 

 180 of sarcosine oxidase, 296 

 Acetazolamide (Diamox), 



distribution in central nervous system. 

 396-397, 399-400 



in ocular tissues, 398 

 rate of fall in tissues, 643 

 Acetone, use in lowering dielectric con- 

 stant, 801 



Acetylcholine, 



inhibition of formation, 466-467 

 of inactivation, 467-470 

 Acetylcholinesterase, see Cholinesterase 

 Achromobacter, inhibition of lumines- 

 cence by HgCla, 786-787 

 Acid-base catalysis, enzymic. 30 

 Acids, proton association constants, 656 

 Aconitase, inhibition by fluorocitrate, 

 436 



trans- Aconitate. 



inhibition of fumarase, eiJect of pH on. 



691-692 

 Activation energy, effect of dielectric 



constant on, 807 

 Activation of substrate, definition of, 28 

 Activator, 



definition of. 45 



effects on enzyme kinetics, 45-47 



inhibition by reaction with. 82-85 

 in systems involving, t>T)es of plot- 

 obtained, 165 



reaction of inhibitor with. 89-90 



Activator inhibition. 131 



Active center, 

 area of. 194 



composition of, 194-197 

 definition of. 194 

 examples of, 200-201 

 flexibility of, 199-203 

 heterogeneity of, 108-109 

 nature of, 194-204 

 of acetylcholinesterase, 200 

 of carboxypeptidase, 201 

 of cytochrome c reductase, 200 

 of fumarase, 201 

 of papain, 201 

 of prolidase, 200 

 of sarcosine oxidase. 201 

 reactions occurring at, 13 

 relation of structure to inhibition. 

 203-204 



terminology of, 50 

 topography of, 197-198 

 two on an enzyme, 36-39 

 types of, 199 



Activity coefficients, 



dependence on ionic strength, 816 

 use in enzyme kinetics, 26-27 

 Activity metabolism, inhibition of, 484 

 Acyl dehydrogenases, enzyme-substrate 

 complexes of, 19 



Adaptation. 



of cells to inhibitors, 



effect on rate of inhibition, 578-579 

 prevented by second inhibitor, 506- 

 507 



919 



