SUBJECT INDEX 



925 



inhibition by diisopropylfluorophos- 

 phate, 187 



effect of pH on, 707 

 inhibition by proteins, effect of ionic 

 strength on, 837 



by D-tyrosinamides, 309, 311 

 inhibitions of, effect of ionic strength 

 on, 836 



nature of K,„, 21 



pH optima of, effect of methanol on, 

 661-662 



Cilia, of Mytilus gill, 



effect of pressure on, 389 



Citrate, inhibition of fumarase, 

 effect of pH on, 691-692 



Cleavage, 



inhibition by urethane, effect of tem- 

 perature on, 790-791 

 inhibition of, effect of pH on, 721 



Closed systems, definition of, 320 



Coenzymes, 



inhibition by reaction with, 82-85 



reaction of inhibitor with, 89-90 

 Colpidium, 



inhibition by arsenicals, reversal by 



thioglycolate, 646 



rate of killing by HgClj, 593-595 

 Compart mentalization , 



effect on transition between steady 



states, 391 



on transit time, 373-379 



in glycolytic pathway, 365 



of intracellular enzymes, 432-435 

 Competitive displacement, of inhibitor 

 by substrate, 



rate of, 612-615 



Competitive inhibition, 



by substrate, 116, 118 



definition of, 54-55 



dilution effect on, 76 



discovery of, 9 



distinction between kinetic and equi- 

 librium competitions, 558 



effect of adding substrate on, 612-615 

 of dielectric constant on, 806 

 of endogenous metabolism on, 445 



of pH on, 659. 668-670. 682-683 



of pressure on, 846-847 



of substrate diffusion into cells on, 



35 



of temperature on, 750-751 

 equations for, 57 

 impossibility in zone C, 74 

 in diffusion-limited systems, 475-477 

 influence of substrate inhibition on, 

 134-139 



intracellular, 475-478, 742-744 

 isobolograms, for, 184-185 

 methods of plotting, 150-153 

 mutual depletion systems, 72-75 

 of forward and backward reactions, 

 101 



of monolinear chains, 332-334 

 of substrate-inhibited enzymes, 178 

 rate of, 552-558 



of reversal of, 610 

 ratio K,/K„ 104-105 

 specificity of, 871 



two inhibitors on single enzyme, 489. 

 496 



variation of K, with substrate, 105-106 

 with respect to activator, 83-84 



types of plots obtained 168-169, 



171-172 



Concentration factor, in inhibitor distri- 

 bution, 399 



Concentration of inhibitors in tissues, see 

 also Distribution of inhibitors, methods 

 of expressing. 394 



Concentration-time curves, for inhibi- 

 tions. 595-603 

 examples of, 598-599 

 interpretation of, 599-603 

 methods of plotting, 596-597 



Concurrent blocking of convergent chains, 

 501 



Constants of inhibition, 



generalized equations for, 154-157 

 methods for determination of, 149-191 



Convergent chains, 340-341 

 effects of temperature on, 770 

 multiple inhibition of. 500-501 



