928 



SUBJECT INDEX 



of freely rotating dipoles, 213-214 

 potential energy of, 212-214 



Dipole-induced dipole interactions, 222- 

 223 



Dipole moments, 

 definition of, 208 



dependence on inductive and resonance 

 effects, 308 

 induced, 218 



in interaction of halogen groups with 

 cholinesterase, 288-289 

 of bonds, 216, 220 

 of molecular groups, 222 

 of molecules in solution, 210-211 

 of rotating molecules, 208-209 



Dipyridyl, see 2,2'-bipyridine 



Diseases, mimicked by inhibitors, 7 



Dismutation, kinetics of. 47-48 



Dispersion electrons, number of, 225- 

 226 



Dispersion energy. 



of benzene ring and alkyl groups, 299 



of steroids and adenine nucleotides, 



298-299 



of two benzene rings. 298 



Dispersion forces, see electrokinetic in- 

 teractions 



Dissociation constants. 



effect of ionic strength on, 818-823 

 of pressure on. 842-843 

 of temperature on. 749-750 



Distortion energy. 262-264 



of enzyme charge distribution. 263 

 of enzyme side-chains, 263 

 of enzyme structure, 263 

 of inhibitor structure, 263 



Distribution of enzymes, intracellular. 

 432-435 



Distribution of inhibitors. 393-425 

 acetazolamide, 396-400. 402 

 arsenite. 395 



chlorguanide. 294-395. 399 

 chlormerodrin, 396-397 

 concentrations in tissues, 394-398 

 correlation with enzyme inhibition. 405 



dependence on binding to plasma pro- 

 teins, 404 



on cell permeability, 402-403 



on dose of inhibitor, 399-400 



on route of administration, 398-399, 



406-407 



on tissue composition, 404 



on tissue vascularity, 400-402 



diisopropylfluorophosphate. 395 



during repeated administration, 421- 



424 



effect of second inhibitor on, 503 



in plants, 405-410 



intracellular. 410-412 



isoniazid. 396-398, 402 



mercuric chloride, 395 



quinacrine, 395 



relation to affects produced, 425 



time course of, 413-421 

 Distributive systems, 346-348 

 Divergent chains. 



effects of temperature on, 771 



multiple inhibition of, 501 



nature of, 341-345 



stimulation of one branch by inhibitor, 



454-455 



DXP. see 2,4-Dinitrophenol 



Dose of inhibitor, effect on tissue dis- 

 tribution, 399-400 



DPX, see Diphosphopyridine nucleotide 



DPXH-peroxidase. complex with DPXH, 

 19 



DPX"-pyrophosphatase, natural inhibi- 

 tors of. 778 

 Dye reduction, inhibition of, 101-104 



EDTA, see Ethylenediamine tetraacetate 



Effective concentration of inhibitor, def- 

 inition of. 411 



Ehrlich ascites tumor cell, see Ascites tu- 

 mor cell 



Electrical field strength, surrounding an 

 ion, 206 



