SUBJECT INDEX 



929 



Electrical potential, of ions, 207 



Electrokinetic interactions, 223-228 

 carboxypeptidase inhibition, 292-294 

 London formulation of, 224 

 of benzene rings, 299 

 of steroids and adenine nucleotides, 

 298-299 



potential energy of, 224 

 Slater-Kirkwood formulation of, 224- 

 225 

 specificity of, 228 



Electron displacement, role in enzjnne 

 reactions, 30 



Electronegativity, 

 definition of, 206 

 of biologically important atoms, 215 



Electronic polarization, definition of 217 



Electron transport, 



inhibition of dye reduction in, 101-104 

 localization of site of inhibition in, 

 517-518 



Electrostriction , 

 definition of, 842 

 role in pressure effects, 841-842 



Endogenous metabolism, 441-447 



effects of added substrate on, 442-443 

 effects on inhibition kinetics, 444-447 

 necessity of correction for. 441-442 



Energy constants, for nonpolar mole- 

 cules, 237 



Energy contours, of enzyme reactions, 21- 

 22, 28-29 



Energy flow, modification by inhibitors. 

 1-3 



Energy of activation of enzyme inhibi- 

 tion, 559-561 



Energy of interaction, see Interaction 

 energy 



Energy, potential, 



of two ions, 207-208 

 Enolase, 



effect of dielectjic constant on, 814- 



815 



substrate inhibition. 111, 131 

 effect of ionic strength on, 838 



Enthalpy, 



determination of changes in, 265-266 

 of hydration, 251 



Entropy, 



determinations of changes in, 265-266 

 electrostatic and nonelectrostatic com- 

 ponents, 265 



formation of ES complexes, 266-267 

 of activation, of enzyme inhibition, 

 559-561 



of hydration, 251 



relation to changes in water structure, 

 266 



Enzyme-inhibitor complex, 

 ionization of, 682-683 

 rate of dissociation of, 607-611 



Enzyme-product complex, effect on ki- 

 netics of, 23-24 



Enzymes, 



charge on, effect on K,-, 694-701 



determination of concentration of, 71- 



72 



development of concepts of, 7-8 



intracellular distribution, 432-435 



intracellular state, 436 



reaction rates, factors determining, 



31-32 



synthesis of, inhibition of, 440-441 



variability of. response to inhibitors 



485-486 



Enzyme-substrate complex, 

 entropy for formation, 266 

 evidence for, 19 

 nature of, 27-31 



Equation of fit, applied to enzyme inter- 

 actions, 302-303 



Equilibrium competition, definition of, 

 558 



Equilibrium distance, 



determination from K,, 270-274 



expressions for, 230-240 



of carboxylate and amino groups, 270- 



273 

 Equilibrium interaction energy, 230-232 

 Erythrocj'tes, respiration of, 



stimulation by quinones, 452 



