SUBJECT INDEX 



933 



Inhibitor constants (K,), 



determination of. 677-682, 684 



from intracellular inhibition. 475- 



478, 737-738 



in multienzyme systems, 382-383 



suggestions for, 188-191 

 effect of dielectric constant on, 804-807 



of ionic strength on, 818-823 



of pressure on, 844 



of temperature on, 748-749 

 variation with substrate, 105-106 



Inhibitor-resistant metabolism, 

 due to polylinear chains, 345 

 explanations of, 449-451 

 for cyanide, 447-448 

 for iodoacetate, 449 



Inhibitors, 



as drugs, 6-7 



history of, 7-11 



reaction with substrate, 



isobolograms for, 186 



types of plots obtained, 165, 173 

 Inhibitor titer, determination of relative 



enzyme concentrations, 80 

 Inhibition index, definition of, 106 

 Insecticidal action, enzjTne basis for, 



473-474 

 Interaction, 



between inhibitors on enzyme surface, 



490-493 



constants, 



determination of, 181-182 

 effect on inhibitions, 61-64 



definition of, 51 



energy, 



dependence on fit, 301-304 

 general equations for, 232 

 of methyl group in a cavity, 301-302 

 relation to inhibitor constant, 264 



forces, 



in colloids, 244 



relative contributions of, 242-245 



Intermolecular forces, classification of, 

 205 



Intracellular concentrations, 

 of enzymes, 482-483 



of inhibitors, 477-478 



maximal level of, 415 



relation to external concentration, 



411 



variation with time, 413-421 

 of substrates, 477-478, 482 



Intracellular enzymes, differences from 

 extracted enzymes, 428 



Intracellular equilibria, effect of inhi- 

 bitors on, 456-458 



Intracellular inhibition, 



determination of K^ from, 475-477 

 effect of diffusion on, 475-477 

 quantitative expression of, 474-478 



Intracellular media, ionic composition of, 

 430-431 



Intrinsic constants, see Microscopic con- 

 stants 



Invertase, see /?-Fructofuranosidase 



lodoacetamide, effect on dinitrophenol 

 inhibition of gastric secretion, 504-505 



Iodoacetate, 



accumulation of hexose phosphates, 

 514 



effect on glucose concentration in 

 lymph cells, 504 

 on heart, 



continuation of inhibition after 

 removal of inhibitor, 579 

 rate of, 586-588 

 on muscle pH, 718-719 

 on photosjnithesis, 519 

 inhibition of cardiac metabolism, 516 

 of fermentation, effect of pH on, 726 

 of glycolysis, 



early work on, 10 

 pyruvate addition to localize, 472 

 rate of, 582-588 

 specificity of, 877-878 

 of pyruvate oxidation, 877-878 

 of respiration, 



effect of pH on, 731 

 rate of, 582-588 

 of sarcosine oxidase, 296 

 of stimulated brain slices, 480 



