934 



SUBJECT INDEX 



inhibition by, effect of pH on, 722-724 



pH of solutions of, 707 



pyruvate utilization during inhibition 



by, 515-516 



rates of inhibition of glycolysis, 582-588 



reaction with glutathione, effect of pH 



on, 726 



resistant fraction of glycolysis, 449 



specificity of, 877-878 



stimulation of yeast respiration, 452 



o-Iodosobenzoate, inhibition of succinate 

 oxidase, 

 rate of, 547, 549-550 



lon-dipole interactions, 208-211 



contributions of various forces to, 243 

 dependence on orientation 209 

 for rotating dipoles, 208-209 

 potential energy of, 208-210 



Ionic atmosphere, 260-262 



effect on ion-ion interactions, 260 

 energy for displacement of, 262 



Ionic radii, table of, 251 



Ionic refractions, 221 



Ionic strength, 



classification of effects of, 815-818 

 effect of substrate concentration on, 113 

 effect on activity coefficients, 816 

 on carboxypeptidase, 830, 837 

 on cholinesterase, 827-828 

 of a-chymotrypsin, 828-829, 836- 

 837 



on cytochrome oxidase, 832 

 on dielectric constant, 815-816 

 on dissociation constants, 818-823 

 on enzyme inhibitions, 835-838 

 on enzyme reactions, 826-834 

 on inhibition of carboxypeptidase, 

 837 



on inhibition of cholinesterase, 836 

 on inhibition of a-chymotrypsin, 836- 

 837 



on inhibition of trypsin, 836-837 

 on ionization constants of enzymes, 

 816-817 



on polynucleotide phosphorylase, 

 831-832 



on proteinase C, 829 



on rate constants, 823-826 



on ribonuclease, 830-831 



on substrate inhibition, 126-128, 133, 



838 



on urease, 828 



Ion-induced dipole interactions, 217-222 

 polarization of benzene ring by ionic 

 group, 298 

 potential energy of. 218-219 



Ion-ion interactions, 



contributions of various forces, 243 

 displacement of water during, 271, 279 

 effect of dielectric constant on, 248-249, 

 804 



of hydration on, 250 

 entropy of, 265 

 index of fit. 303-304 

 in hapten-antibody reactions, 279-280 

 potential energy of, 207 



Ionization constants, 

 effect of buffers on. 840 

 of active center groups, effect of 

 charged inhibitors on, 701-704 



Ionization potential, dispersion energy 

 and. 224 



lon-nonpolar interactions, contributions 

 of various forces, 243 



Ions, 



binding in the cell, 431 



cavity size of, 240-241 



concentrations in tissues, 430-431 



electrical potential of, 207 



field strength of, 206 



potential energy between, 207-208 



specific binding to proteins, 818 



Iproniazid, inhibition of monoamine oxi- 

 dase. 



entropy of activation of, 561 

 in different tissues, 405-406 

 protection by tyramine, 558 

 rate of, 545, 548 

 time course in liver, 406 



Irreversible inhibition, definition of, 52- 

 54 



