SUBJECT INDEX 



935 



Isobolograms, 



competitive inhibition, 185 

 expression of antagonism, summation, 

 and synergism, 508-509 



of inhibitions, 183-184 

 reaction of inhibitor with substrate, 186 

 two inhibitors acting simultaneously, 

 495-498 



Isoniazid, distribution in central nervous 

 system, 396-398, 402 



Isoxanthopterin, inhibition of xanthine 

 oxidase, 120, 124, 137-138 



a-Ketoglutarate utilization, stimulation 

 by malonate, 452 



Kinetic competition, definition of, 558 

 Kinetic constant, definition of, 20 

 Kinetic energy of molecules, effect on 

 interaction distance, 238-240 



Kinetics, 



complex enzyme reaction tjT)es. 32-48 

 diffusion of substrate to enzyme, 34-35 

 Michaelis-Menten formulation of, 14 

 of enzyme reactions, 

 cyclic reactions, 47-48 

 effect of activator on, 45-47 

 of EP complex on, 23-24 

 of number of substrate molecules 

 bound, 25-26 

 of pH on, 652-666 

 of reversibility, 24-25 

 of substrate depletion on, 22-23 

 enzyme concentration greater than 

 substrate, 35-36 

 participation of solvent, 43-45 

 two different substrates. 39-43 

 two interdependent active centers, 

 36-39 



use of activities in, 26-27 

 of inhibition, 



dependence on inactive forms of 

 enzyme, 760-767 

 destruction of inhibitor on, 100 

 development of, 9 



effect of endogenous metabolism, 

 444-447 



of enzyme inactivation on, 561- 



569 



of nonenzymic binding on. 615-620 



of pH on, 667-677 



of substrate and inhibitor concen- 

 trations on, 61-64 

 generalized equations for, 55-59 

 influence of substrate inhibition on, 

 134-139 



inhibition of forward and backward 

 reactions, 100-101 

 inhibitor also a substrate, 96-98 

 more than one inhibitor molecule per 

 enzjTiie molecule, 90-96 

 progressive inactivation of enzyme, 

 98-100 



reaction with coenzyme or activator, 

 89-90 



with coenzyme or activator sites, 



82-85 



with substrate, 85-88 

 reduction of acceptor, 101-104 

 reversible and irreversible, 52-54 

 substrate diffusion into ceUs, 35 

 two inhibitors on a single enzyme, 

 488-492 

 Krupka-Laidler plot, determination of K,- 

 in mutual depletion systems, 188 



Lactate dehydrogenase, 

 complexes with DPX, 19 

 distribution in nervous system, 483 

 inhibition by ^-chloromercuribenzoate, 

 rate of, 546, 549 . 



reversal by cysteine and GSH, 622 *^ 

 inhibition by excess apoenzyme, 455 



by substrate analogs. 297 

 localization in staphylococcal mem- 

 brane, 434 



substrate inhibition. 111, 121-122, 124- • 

 125 



Lag period, see Latent period 



Latent period, of inhibition, 573 



of Aspergillus respiration by C'u++, 582 



