936 



SUBJECT INDEX 



Lethal synthesis, 



definition of, 437 



effect of a second inhibitor on, 502-503 



examples of, 437 



kinetics of, 437-439 

 Limiting reactions, 



concept of, 380-382 



definition of, 320 



limiting rare coefficient, 381 



role in complex enzyme kinetics, 48 

 Lipase, 



effect of temperature on, 766-767 



substrate inhibition. 111 

 Lipid content of tissues, table of, 401 

 Liver, respiration of, 



stimulation by quinones, 452 



Localizations, of site of inhibition, 513- 

 533 



accumulation of intermediates, 513-515 

 addition of substrates or intermediates, 

 515-516 



distribution of labeled atoms, 519-521 

 general program of localization, 527-533 

 reconstructed enzyme systems, 523 

 spectroscopic analysis, 516-519 

 uncoupling mechanism, 523-527 

 use of second inhibitor, 521-522 



London forces, see Dispersion energy, 

 Electrokinetic interactions 



M 



Magnesium, 



concentration in tissues, 430 

 distribution in cells, 431 



Malate dehydrogenase, 



distribution in nervous system, 483 

 inhibition by j^-chloromercuribenzoate, 

 failure of cysteine nad GSH to reverse. 

 622 



localization in staphylococcal membra- 

 ne, 434 

 stimulation by arsenite, 452 



Malate, inhibition of fumarase, 

 effect of pH on, 691-692 



Maleate, inhibition of fumarase, 

 effect of pH on, 691-692 



Malonate, 



antagonism of citrate accumulation due 

 to fluoroacetate, 502-503 

 inhibition of bacterial dehydrogen- 

 ases, 9 



of fumarase, effect of temperature 

 on, 754 



of respiration, effect of pH on, 722- 

 723 



of stimulated brain slices, 480 

 of succinate dehydrogenase, 104 

 dependence on rate of reaction, 

 858 



determination of Kj/K^, 183 

 distortion of structures, 263 

 effect of dielectric constant, 806 

 effect of temperature on, 754 

 pH of solutions of, 707, 709 

 protection of succinate dehydro- 

 genase against SH-agents, 494 

 resistance to, 450 

 specificity of, 878 

 stimulation of ATPase, 453 

 of cardiac respiration, 521 

 of a-ketoglutarate oxidation, 5, 521 

 of a-ketoglutarate utilization, 452 

 of pyruvate incorporation into cy- 

 cle, 452 

 use to study a-ketoglutarate oxidation, 

 5. 521 



Mechanisms of inhibition, classification 

 of, 50-51, 60-61 



Media, for enzyme experiments, 

 composition of, 428-432 



Membranes, localization of enzymes in, 

 433-435 



Menadione, inhibition of bioluminescence, 

 effect of pH on, 744-745 



Mepacrine, see Quinacrine 



Mercurials, see Chlormerodrin, ^j-Chloro- 

 mercuribenzoate, Mercuric chloride 



Mercuric chloride, 



concentrations in tissues, 395 

 inhibitions of bioluminescence, effect 

 of temperature on, 786-787 



