SUBJECT INDEX 



937 



of cholinesterase, effect of temper- 

 ature on, 758 



of glycolysis, rate of, 580-581 

 of respiration, rate of, 580-581, 588- 

 590 



of succinate oxidase, partial rever- 

 sal by dimercaprol, 622 

 rate of killing of Colpidium, 593-595 



Mercuric dimer of seralbumin, thermo- 

 dynamics of, 267 

 Mesaconate, inhibition of fumarase, 



effect of pH on, 691-692 

 Metabolic differentiation, detection with 



inhibitors, 5-6 

 Metabolic rate, effect on inhibitions, 857- 



862 



Metabolic variation, between different 

 tissues, 481-484 



Metabolism of inhibitor, 



effect of a second inhibitor on, 502-503 

 effect on rate of inhibition, 577-578 



Methane, 



dispersion electrons of, 225 

 energy constants of, 237 

 energy curve for interaction, 236 

 interaction energy of, 237 

 molar refraction of, 225 

 optical constants of, 225 

 polarizability of, 225 



Methanol, 



dipole moment of, 244 



effect on pH optimum of a-chymo- 



trypsin, 661 



interaction energy contributions of. 



244 



use in lowering dielectric constant, 801 



Methoxyacetate, inhibition of sarcosine 

 oxidase, 295-297 



Methylene blue, inhibition of reduction 

 by dehydrogenases, 101-104 



Methylene group, 



binding energy to carboxypeptidase, 

 292 



to lactate dehydrogenase, 297 



to sarcosine oxidase, 297 



configuration of, 235 



dispersion energy for interaction with 



protein, 300 



van der Waals radius of, 234 



Methyl group, 



binding energy to sarcosine oxidase. 



297 



configuration of, 235 



dipole angle of, 222 



dipole moment of, 222 



dispersion energy in hapten-antibody 



reactions, 278 



index of fit in protein cavity, 303-304 



interaction energy in protein cavity, 



301-302 



interaction with benzene ring, 299 



molar refraction of, 222 



polarizability of, 299 



van der Waals radius of, 234 



iV'-Methylnicotinamide, inhibition of al- 

 cohol dehydi-ogenase, due to conta- 

 minating Ag+, 857 

 Methyl orange 



binding to seralbumin, 314-315 

 effect of temperature on, 753 



binding to various proteins, 317 

 Michaelis constant (K^) 



definition of, 15, 17 



determination of, 16 



effect of pressure on, 843 

 of temperature on, 748-749 



energy contours and, 21 



expression for, 20 



table of values of, 18 

 Michaelis-Menten kinetics, validity of, 



17-27 

 Microscopic constants, applied to K,, 



95-96 

 Miotine, inhibition of cholinesterase, 71 

 Mixed inhibition, 



detection of, 160 



equations for, 58 



types of plots obtained, 162 

 Molar refraction, 



definition of, 218 



double bond conjugation and, 219 



