938 



SUBJECT INDEX 



of atoms, 219 



of bonds, 220 



of ions, 221 



of molecular groups, 222 



of protein sites, 277 

 Molecular group refractions, 222 

 Molecular structure, alterations of, 



classification of, 305 



effect on inhibitions, 306-307 

 on properties, 304-312 



examples of, 308-311 



on type of inhibition, 310-311 



optical isomers, 309-310 

 Monoamine oxidase, inhibition by ipro- 



niazid, 



entropy of activation of, 561 



protection by tyramine, 558 



rate of, 545, 548 



synthesis of new enzyme following, 645 

 Monolinear chains, 



irreversible, 



buffer capacity of, 331-332 



concentrations of intermediates, 323- 



324, 327-331, 333-335 



diffusion-limited, 335-337 



effect of temperature on, 769-770 

 of two inhibitors on, 498-500 

 inhibition of, 327-335 

 of several steps, 337 

 over-all rate factors, 323-327 

 reaction of inhibitor with interme- 

 diates, 334-335 



reversible, 



concentrations of intermediates, 338- 



340 



noncompetitive inhibition of, 338- 



340 



Multienzyme systems, 



branched linear chains, 340-345 



classification of, 321-322 



compartmentalization of, 377 



cyclic systems, 348-354 



definition of, 319 



determination of K, and K, in, 382- 



383 



distributive systems, 346-348 



effect of pH on inhibition of, 711-713 



of steady-state rate on inhibition of, 



859 



of temperature on, 768-773 

 limiting rate concept, 380-382 

 monolinear chains, 322-340 

 multiple inhibition of, 500-501 

 network systems, 372 

 polylinear chains (shunts), 345-346 

 product inhibition in, 147-148 

 regenerative systems, 354-368 

 self-regulatory (feedback) systems, 368- 

 372 



structural disruption of, 379 

 terminology of, 320-322 

 transition time between steady states, 

 383-391 



transit time, 373-377 

 use of inhibitors in, 5 

 Multiple inhibition, 487-512 



antagonism, summation, and synergism 



507-510 



expression by isobols, 495 



of bioluminescence, 510-512 



of cholinesterase, 493-495 



of succinate oxidase, 492-493 



specificity of, 510 



two inhibitors. 



on cellular metabolism 502-507 



on monolinear chain, 498-500 



on one enzyme, 488-498 



on various multienzyme systems, 



500-501 

 Multipoint attachment, 



of substrate to active center, 28 

 relation to catalysis, 197-198 

 role in substrate inhibition, 113 



Multipoles, 228-229 

 Muscle, respiration of, 



stimulation by quinones, 452 

 Mutual depletion systems, 66-78 



boundary conditions in, 69-71, 75 



cellular, 77-78 



competitive inhibition in, 72-75 



dilution effects in, 76-77 



effect of nonenzymic binding of inhi- 

 bitor, 854-857 



of pH on inhibitions in, 706-707 



