SUBJECT INDEX 



939 



extraneous substances, role in, 78 

 noncompetitive inhibition in, 66-72 

 of inhibitor and reversor, 618-620 

 rate of inhibition in, 548-552 

 steady-state kinetics in, 75 

 types of plots obtained, 184-188 

 Myosin, binding of K+ and Na+, 262, 818 



N 



Naturally occurring inhibitors, effect of 



temjjerature on, 778-779 

 Neohydrin. see C'hlormerodrin 

 Neostigmine, inhibition of cholinesterase, 



effects of tetraalkylammonium ions on, 



495 

 Network systems, 372 

 Nitella 



lethal action of Cu++, concentration- 

 time curves for, 598 



penetration of cresyl blue into, 602 

 Nitric oxide, optical constants of, 225 

 Nitrogen, 



dispersion electrons of, 225 



energy constants of. 237 



energy curve for interaction, 236 



interaction energy of, 237 



molar refraction of, 225 



optical constants of, 225 



polarizability of, 225 

 Nitro group, 



bond angle of, 240 



dipolc angle of, 222 



dipole moment of, 222 



dispersion energy in hapten-antibody 



reactions, 278 



molar refraction of, 222 

 Nitrous oxide, optical constants of, 225 

 Noncompetitive inhibition, 



by products, 143-144 



by substrate, 114, 118-120 



definition of, 54-55 



dilution effect on, 76 



discovery of, 9 



effect of endogenous metabolism on, 



445-447 



of ionic strength on, 821 



of pH on, 659, 671-673 



of temperature on, 749-751 

 equations for, 58 



in diffusion-limited systems, 475-477 

 influence of substrate inhibition on, 134 

 intracellular, 475-477 

 more than one inhibitor combines with 

 enzyme, 90-96 



mutual depletion systems, 66-72 

 of cyclic systems, 351-362 

 of divergent chains, 343 

 of forward and backward reactions, 

 100-101 



of monolinear chains, 327-332 338-340 

 of regenerative systems, 364-366 

 of self- regulatory (feedback) systems, 

 370-372 



of substrate-inhibited enzymes, types 

 of plots obtained, 177, 179 

 progressive destruction of inhibitor 

 during, 100 



progressive inactivation of enzyme dur- 

 ing, 98-100 

 rate of, 541-548 



of reversal of, 610 

 specificity of, 866-870 

 transition time between steady states, 

 384-386 



two inhibitor molecules bound to en- 

 zyme, types of plots obtained, 174, 489, 

 496 



types of plots obtained, 158 

 with respect to activator, 83, 



to substrate, 54-55, 58 



Nonenzymic binding of inhibitors, 615- 

 624, 854-857 



effect on inhibitions, 615-620 

 examples of, 622-624 

 reversal of inhibition by, 620-622 



Nonenzymic effects of inhibitors, on 

 cellular function, 463-464 



Nonenzymic material, 



binding of inhibitors to, effect on rates 



of inhibition, 577 



in mutual depletion systems, 78 

 Nu 683, inhibition of cholinesterase, 71-72 



