940 



SUBJECT INDEX 



Open systems, definition of, 320 

 Optical constants, for simple molecules, 



225 

 Optical isomerism, importance in group 



effects on inhibition, 309-310 

 Optimal temperature, effect of inhibition 



on, 767-768 

 Organophosphorus compounds, see also 

 Diisopropylfluorophosphate 



inhibition of cholinesterase, 



effect of temperature on, 759-760 

 induced reactivation, 630-636 

 spontaneous reactivation, 627-630 



insecticidal action, 473-474 



poisoning by, 



kinetics of reversal, 646-648 

 treatment with reactivators, 636 

 Organ weights, table of, 401 

 Orientation polarization, 



definition of, 217 



of permanent dipole, 208 

 Overshoot, in transition between steady 



states, 386-388 

 Oxidation -reduction reactions, kinetics 



of, 47-48 

 Oxidative phosphorylation, example of 



regenerative system, 366-368 



Oxophenarsine, binding to erythrocytes, 

 reversal of, 644 



Oxygen, 



difi'usion rate into erythrocytes. 573 

 dispersion electrons of. 225 

 molar refraction of, 225 

 optical constants of, 225 

 polarizability of, 225 



Pacemakers of metabolism, see also Lim- 

 iting reactions 

 definition of, 459 

 examples of, 459 

 in ascites tumor cells, 461 

 restriction of concept, 460 



Paludrine, see Chlorguanide 



Papain, 



active center of, 201 



degradation by leucine aminopepti- 



dase, 195 



effect of dielectric constant on, 812- 



813 



inhibition by carbobenzoxy-L-gluta- 



mate, effect of pH on, 667-668 



nature of SH group at active center, 



196 



stimulation by arsenite, 452 



Paramecia, lethal action of arsenite, 

 kinetics of, 600 



Partially competitive inhibition, 

 detection of, 160 

 types of plots obtained, 159 



Partially noncompetitive inhibition, ty- 

 pes of plots obtained, 161 



Penetration of inhibitors into tissues, 

 see also Permeability to inhibitors 

 effect of functional activity on, 577, 588 

 of membrane depolarization on, 484 

 on rate of inhibition, 573-576 

 malonate, 402-403 

 rough classification of, 403 



Pepsin, 



entropy changes in formation of ES 

 complex, 266 

 enzyme-substrate complex, 19 



Permeability to inhibitors, see also Pene- 

 tration of inhibitors into tissues 

 effect on distribution, 402-403 

 relation to ionization. 721-726 



Permeases, concept of. 439 



Peroxidase. 



diffusion-limited steady-state system 

 of, 335-337 



enzyme-substrate complex, 19 

 heme in protein crevice, 198 

 nature of K^, 21 



pH, 



effect on enzyme inhibition. 649-745 

 on inhibition in multienzyme sys- 

 tems, 711-713 



