942 



SUBJECT INDEX 



Plasma membrane, 



inhibition of transport in, 439-440 

 localization of enzymes in, 433-435 



Plasma, proteins, binding of inhibitors to, 

 404 



Plotting, see Graphical analysis 



Polarizability, 



asymmetry of, 219-220 



definition of, 217 



of atoms, 219 



of bonds, 220 



of molecular groups, 222 



Polarization, 



atomic, definition of, 217 



electronic, definition of, 217 



induced, definition of, 217 



orientation, 



definition of, 217 



of permanent dipole, 208 



role in induced dipole interactions, 



217-218 

 Polyanions, inhibition of trypsin, 



effect of ionic strength on, 836-837 

 Polyglutamate, inhibition of trypsin, 



effect of ionic strength on, 836-837 

 Polylinear chains (shunts), 345-346 



effect of temperature on, 772 



multiple inhibition of, 501 

 Polynucleotide phosphorylase, effect of 



ionic strength on, 831-832 

 Potassium, 



concentration in tissues, 430 



intracellular binding of, 431 

 Potential, electrical, 



of ions, 207 

 Potential energy, of two ions, 207-208 

 Potentiation, see Synergism 

 Preincubation procedures, for determin- 

 ing site of inhibitor action, 569-571 

 Pressure, effects of, 841-854 



as transitions between steady states, 



389-390 



mechanisms of, 841-842 



on cellular inhibitions, 849-854 



on dissociation constants, 842-843 



on enzyme inhibitions, 846-849 

 on enzyme rates, 845-846 

 on rate constants, 843-844 



Primary hydration, 



definition of, 250 



of common ions, 251 

 Primary salt effect, definition of, 824 



Product inhibition, 140-148 



by formation of inactive enzyme com- 

 plex, 143-144 



by reversal of enzyme reaction, 140-143 

 examples of, 144-147 

 in multienzyme systems, 147-148 

 of arylamine transacetylase, 145 

 of cholinesterase, 146 

 of glutathione synthetase, 145 

 of glycine transacylase, 145 

 of hexokinases, 144, 148 

 of pyridoxal phosphokinase, 145 

 of urease, 145-146 

 types of plots obtained, 180 



Proflavine, bacterial adaptation to, 



as transition between steady states, 389 

 Prolidase, active center of, 200 

 Prosthetic group, definition of, 50 

 Proteinase (', effect of ionic strength on, 

 829 



Proteins, 



charge on. effect of binding to ions, 

 315-316 



hydration of, 258 

 interactions with small molecules, 

 competition for binding sites, 313- 

 314 

 effect of temperature on, 316 



of total protein charge on, 315-316 

 multiple binding sites, 314-315 

 specificity of, 316-317 

 Proton association, rates of, 656 

 Pseudo-irreversible inhibition, 78-82, 855 

 Pseudo-steady state systems, 321 

 Pseudo-substrate inhibition, illustration 



of. 113-114 

 Pyridine-2-aldoxime methiodide (2-PAM), 

 reactivation of cholinesterase, 631-633 



