944 



SUBJECT INDEX 



oxidation-reduction reactions, 363-365 

 phosphate transfer, 365-368 

 steady-state conditions of, 359-360 



Relative concentrations, see vSpecific con- 

 centrations 



Relative interaction energies, determina- 

 tion of, 268-270 



Repeated administration of inhibitors, 

 421-425 



Repulsion, 



correction factors for, 231-232 

 interactions in, 229-231 

 orientation factors in, 241-242 



Resistant metabolism, see Inhibitor- 

 resistant metabolism 



Respiration, 



hypoxic depression of, effect of tem- 

 perature on, 782 



inhibition by cyanide, effect of tem- 

 perature on, 782-784 



by heavy metal ions, rate of, 581- 



582, 588-590 



by urethane, effect of temperature 



on, 790 

 inhibition of, 



effect of pH on, 722-724, 730-731 

 of temperature on, 777-778 



localization of site of. 529-531 

 stimulation by 2,4-dinitropheno]. ef- 

 fect of temperature on. 784-785 



by various inhibitors, 452 



Retardation, factor in dispersion forces, 

 226-227 



Reversal of inhibition, 605-648 



by destruction of inhibitor, 637-642 

 by substance binding the inhibitor, 

 615-622 



competitive displacement of inhibitor 

 by substrate, 612-615 

 dissociation of EI complex, 607-612 

 examples of, 622-624 

 in cells and whole animals, 642-648 

 induced reactivation of inhibited en- 

 zymes, 630-636 

 information from, 624-626 



spontaneous reversal of inhibited en- 

 zymes, 626-630 

 techniques for demonstration, 606-607 



Reversible enzyme reactions, kinetics of, 

 24-25 



Ribonuclease, 



effect of ionic strength on, 830-831 

 enzyme-substrate comijlex, 19 

 inactivation by pepsin, 195 

 substrate inhibition. Ill, 122 



Route of administration, effect on inhi- 

 bitor distribution, 398-399, 406-407 



Salicylate, 



inhibition of D-amino acid oxidase, 90 

 of cholinesterase, effect of tempera- 

 ture on, 758-759 

 of cleavage, effect of pH on, 721 



Salt effects, see also Ionic strength 



specific ion effects on enzymes, 834-835 

 Salting-out effect, definition of, 821 



Sarcosine oxidase, 

 active center of, 201 

 binding energies of inhibitors, 295-297 

 Secondary effects of inhibitors, 457-458 

 Secondary hydration, definition of, 250 

 Secondary inactivation, of enzyme dur- 

 ing inhibition. 561-569 

 Secondary salt effect, definition of, 824 

 Selenite, inhibition of succinate oxidase, 

 effect on temperature characteristics, 

 798 



Self-regulatory (feedback) systems, 368- 

 372 



effect of substrate concentration on, 

 369-370 



examples of, 368-369 

 inhibition of, 370-372 



Sequential inhibition, 



of cycle by malonate and fluoroacetate, 

 498, 502-503 



of phenylalanine metabolism in E. coli, 

 498, 500 



