SUBJECT INDEX 



945 



Seralbumin, binding oi', 



Ca++, 266, 314, 818 



Cr, 313 



Cu++, 266, 314 



dodecyl sulfate, 314 



ions, effect of temperature on, 753 



methyl orange, 314-315 



Mg++, 314 



optically isomeric dyes, 317 



phenylbutyrate, 314 



surfactants, 300 



testosterone, 314, 317 



Zn++, 314-315 

 Serotonin, levels in brain following mo- 



ndamine oxidase i-nhibition, 645 

 Shunts, see Polylinear chains 

 Silver, inhibition of respiration, 



rate of, 581-582 

 Simon-Beevers curves, 728-734 

 Sodium, 



concentration in tissues, 430 



intracellular binding of, 431 

 Solvent, participation in enzyme reac- 

 tions, 43-45 

 Spatial factor, in inhibitor distribution, 



398 

 Specific concentrations, definition of, 



65-66 

 Specificity of inhibition, 



change with time of, 535 



definition of, 510 



examples of, 877-878 



in cellular systems, 871-873 



in competitive systems, 871 



in systems of three or more enzymes. 



869-871 



maximal for two enzymes. 866-869 



multiple inhibition, 510 



with two or more inhibitors, 873-877 

 Spermatozoa, respiration of, 



stimulation by arsenite, 452 

 by quinones, 452 

 Spontaneous reversal of inhibited en- 

 zymes, 626-630 

 Steady state, 



definition of, 320 



in yeast metabolism, effect of cyanide 

 and dinitrophenol on, 389 

 kinetics, 20 



derivation of rate equations, 32-33 

 mutual depletion systems, 75 



relation to type of inhibition, 61 

 of convergent chains, 341 

 of divergent chains, 341-342 

 of monolinear chains, 323-330 

 transitions between, 383-391 



Steroids, 



binding to proteins, 317 



complexes with adenine nucleotides, 



298-299 

 Stimulation of metabolism, by inhibitors, 



451-456 



examples, of, 452 



possible mechanisms of, 453-456 



Streptobacterium casei, glycolysis in, 

 rate of inhibition by iodoacetate, 584- 

 585 



Structural alteration, of multienzyme 

 systems, 379-380 



Substrate, 



concentration of, 



effect on enzyme rates, 14, 35-36 



on inhibitions, 61-64 

 reduction by enzyme binding, 22-23 

 intracellular concentrations of, 482 

 protection against inhibition, 558 

 reaction of inhibitor with, 85-88 



Substrate constant (Kg), 

 definition of, 17 

 variation with pH, 661-666 



Substrate inhibition, 111-139 

 by an ionic strength effect, 133 

 by attachment outside active center, 

 118-130 



by combination with activator, 130- 

 131 



by competition with substrate-acti- 

 vator complex, 132 

 by interference with acceptor binding, 

 132-133 



by partial attachment to substrate 

 sites, 114-117 



