SUBJECT INDEX 



947 



Summation, 



definition of, 507-508 



isobolograms for, 508-509 



of inhibitions on convergent chains, 



501 

 Synergism, 



between fluoride and phosphate on suc- 

 cinate oxidase, 492-493 



definition of, 507-508 



inhibition of phenylalanine metabo- 



Hsm in E. coli, 498, 500 



isobolograms for, 508-509 

 Synthesis of enzymes, inhibition of, 440 



Tartrate, inhibition of fumarase, 



effect of pH on, 691-692 

 Temperature, 



effect on binding of small molecules 



to proteins, 316 



on cellular inhibitions, 773-780, 782- 

 792 



on dissociation constants, 748-749 

 on enzyme inhibition, 750-756 

 on inhibition of cell function, 779- 

 780 



on multienzyme systems, 768-773 

 on rate of inhibition, 558-561, 756- 

 760 



on respiratory inhibition, 777-778 

 on response to anoxia, 780-782 

 on sulfanilamide inhibition of bio- 

 luminescence, 511-512 

 on urethane inhibition of biolum- 

 inescence, 511-512 



equilibria between active and inactive 



forms of enzyme, 760-767 



optimal for enzyme reactions, 767-768 

 Temperature characteristics, 792-798 



definition of, 792 



determination of, 793 



for inhibition of ATPase by dinitro- 



phenol, 797 



for inhibition of cholinesterase by qui- 

 nine, 795-796 



for inhibitions of succinate oxidase, 798 



interpretation of, 793-794 

 of urease, 797 



Temporal factor, in inhibitor distri- 

 bution, 398-399 



Testosterone, binding to seralbumin, 314, 

 317 



Tetraalkylammonium ions, inhibition of 

 cholinesterase, 

 effects of neostigmine on, 495 



Tetraethylpyrophosphate (TEPP), in- 

 hibition of cholinesterase, 

 reactivation by aldoximes, 630-633 



Thermal cavity size, relation to ionic size. 

 241 



Thiocyanate, 



binding to seralbumin, effect of tem- 

 perature on, 753 



inhibition of fumarase, effect of tem- 

 perature on, 754 



Tissue slices, 



binding of inhibitor to nonenzymic ma- 

 terial, 479-480 

 functional state of, 480-481 

 inhibitions in. 479-481 

 penetration of inhibitors into, 479 

 variation between cells in, 481 



effect on rate of inhibition, 594-595 



Titration inhibitors, see Mutual deple- 

 tion systems. Pseudo-irreversible inhi- 

 bition 



Tobacco leaves, photosynthesis in, 

 inhibition by iodoacetamide, 520 



Transacetylases, in distributive systems, 

 347 



Transacetylation, energy contours for, 29 



Transaminase, 



distribution in nervous system, 482- 



483 



in distributive systems, 347 



Transfer reactions, kinetics of, 39-43, 

 47-48 



Transition, 



between steady states, 383-391 

 examples of, 389-390 

 false start, 387-388 



