948 



SUBJECT INDEX 



fluctuation, 386-388 



in metabolic systems, 390-391 



in monolinear chains, 384-386 



overshoot, 386-388 



time required, see Transition time 

 time, 383-386 



importance in enzyme reactions, 



383-384 



variation with inhibition, 385 

 variation with substrate concentra- 

 tion, 386 



Transit time, 373-379 

 definition of, 373 



eiJect of compartmentalization on, 377- 

 379 



on enzyme rates, 373-375 



Translocases, concept of, 439 



Translocation, of inhibitors in plants, 407- 

 410 



Transmethylases, in distributive systems, 

 347 



Transmitters, see Agonists 



Transphosphorylase, inhibition by Na+. 

 838-839 



Transphosphorylation, energy contours 

 for, 29 



Transport systems, inhibition of, 439- 

 440 



Trichomonas, respiration of, 

 stimulation by arsenite, 452 



Trimethylammonium group, 



dispersion energy in interaction with 

 cholinesterase, 245, 287 

 in hapten-antibody reactions, 279, 281 

 interaction with carboxylate group, 279 

 van der Waals radius, 234 



Triose phosphate dehydrogenase, see Pho- 

 sphoglyceraldehyde dehydrogenase 



Trypanosoraes, lethal action of arsenicals, 

 kinetics, of, 598-599, 601 



Trypsin, 



area of active center, 194 

 binding of soybean inhibitor, thermo- 

 dynamic constants for, 267 



effect of ionic strength on inhibition of, 



836-837 



entropy change in formation of ES 



complex, 266 



formation from trypsinogen, 196 



nature of K„,, 21 



Tryi^tophanase, intracellular K^ com- 

 pared with that of extracted enzyme, 

 436 



Tyrosine. 



inhibition of phenylalanine synthesis 



in E. coli, 498, 500 



ionization microconstants for, 703 



u 



Uncompetitive inhibition, see Coupling 

 inhibition 



Uncoupling, 



of oxidative phosphorylation, 523-527 

 criticism of methods for demon- 

 strating, 523-524 

 definition of, 523-526 

 in regenerative systems, 367-368 



Uranium, 



inhibition of transport systems in yeast, 



434 



nonenzymic effects on yeast, 463 



Urease, 



effect of ionic strength on, 828 

 entropy change in formation of ES 

 complex, 266 



evidence for a water site, 43 

 inhibition by phosphate, 839, 841 



by thiourea, 108 

 kinetics indicating two active centers, 

 38 



product inhibition, 145-146 

 substrate inhibition, 43-44, 111 

 temperature characteristics of, 797 



Urethane, 



effect on spectra of yeast cytochromes, 



517 



inhibition of bioluminescence, 510-512 



effect of temperature on, 787-788, 



790 



