614 



Ontogeny of Endocrine Correlation 



roids is dependent mainly upon advances in 

 the understanding of (1) the nature of the 

 properties of the developing skeletal elements 

 that enable them selectively to remove and 

 utilize calcium and phosphate from the blood 

 stream, (2) the mechanisms of deposition of 

 calcium salts in bone, and (3) the time when 

 the parathyroid hormone is produced and 

 released into the fetal blood. A promising 

 approach to the problem of the time of onset 

 of parathyroid activity is that of testing the 

 glands at progressively older developmental 

 stages for capacity to bring about bone re- 

 sorption when grafted beneath the periosteum 

 of bone in young postnatal host animals. 

 The value of this proposal is obvious from 

 the studies of Chang ('51), who showed for 

 young mice and rats that parathyroid tissue 

 when grafted beneath the periosteum of the 

 parietal bone causes a marked local resorp- 

 tion of bone, indicating the emanation of 

 parathyroid hormone from the graft. The 

 effect is highly specific, since other tissues so 

 grafted cause little or no bone resorption. 



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