B VITAMIN DEFICIENCY STATES 433 



results so obtained are of particular interest in that analogues of this 

 vitamin have met with such spectacular success in combatting bacterial 

 infections. 



Of interest from both theoretical and practical standpoints is the work 

 of Williams et al. on genetotrophic diseases. 239 Whereas the realization 

 that there may exist genetically induced high vitamin requirements is 

 not entirely new, the recent coupling of such high requirements with 

 nutritional states to produce a hitherto unconsidered type of deficiency 

 disease merits attention. Experimental evidence has as yet been produced 

 bearing on only one — compulsive drinking. Thus, whereas rats from an 

 ordinary colony normally show a wide range in individual appetites for 

 alcohol as measured by self-selection of water or 10 per cent alcohol, 

 animals on deficient diets tend eventually to drink large quantities of 

 alcohol. The alcohol consumption so induced may be cured by nutritional 

 means by correcting the nutritional deficiency to which the particular 

 animal is subject. The extension of these studies to clinical trials with 

 humans, and to other diseases, 259 should certainly be one of the most 

 fascinating directions in which results are to be expected in the near 

 future in this field. 



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