INTRODUCTION AND THEORETICAL CONSIDERATIONS 457 



-C 2 H 5 , etc.; -NH 2 by -OH, -N0 2 , etc.; -H by -CI, -CH 3 , -OH, 

 etc., and these and other groups by such similar groups. 



A number of excellent reviews by Woolley, 21 24 by Welch, 2 "' and by 

 Roblin 2G have indicated the developments in the general field of competi- 

 tive inhibitors of the biochemical functioning of essential metabolites and 

 have indicated more extensively the changes in structure most likely to 

 produce metabolic antagonists. 



The biological activities of the B vitamins and related compounds in- 

 cluding modifications such as these indicated above are listed in subse- 

 quent chapters. The biological activities in replacing the vitamin are 

 indicated in terms of per cent activity on a molar basis relative to the 

 particular B vitamin. The inhibitory activities are indicated in terms of 

 the inhibition index which, unless otherwise indicated, is the lowest ratio 

 of the concentration of the inhibitor to the concentration of the corre- 

 sponding B vitamin at which maximum inhibition of the biological system 

 occurs. 



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