700 THE BIOCHEMISTRY OF B VITAMINS 



Soodak and Cerecedo 74 reported that oxythiamine inhibits the Chastek 

 paralysis thiaminase, but quantitative data are not available. Bhagvat 

 and Devi 95 found that certain cereals, legumes and oil seeds contain a 

 factor capable of destroying thiamine. Apparently, the factor is not an 

 enzyme, since it is extracted by chloroform-water mixtures and is stable 

 to heat, including autoclaving. The end products are believed to be 

 pyrimidine and thiazole derivatives, since mosquito larvae were able to 

 utilize for growth the breakdown products produced when thiamine was 

 destroyed by extracts from ragi or carp tissue, but were unable to utilize 

 the breakdown products produced by autoclaving or treating thiamine 

 with sulfite or sodium hydroxide. The extraction from the flesh of 

 Corbicula strata of a thiaminase which deaminized the pyrimidine ring 

 but did not open the thiazole ring was announced by Murata. 96 



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