726 



INDEX 



p-Aminobenzoic acid — Continued 



glutamic acid in metabolism of, 487- 

 489 



hydrolytic conditions, 41 



inhibitory analogues, 493-500, 521-530 



isosteres, 527-528 



metabolic relations to purines, pyri- 

 midines, 198 



metabolism of, 363-364 



relation to folic acid, 202, 472, 490-493 



relation to nicotinic acid, 282 



relation to pantothenic acid, 282 



relation to thymidine, 474 



requirements, 326, 327 



role in amino acid synthesis, 201 



role in carbon to carbon bond forma- 

 tion, 189 



role in purine and pyrimidine syn- 

 thesis, 201 



role in single carbon unit metabolism, 

 472 



specificity, 482-483 



structure, 11 



sulfonamide antagonism to, 199 



sulfonamides in inhibition analysis of 

 function, 470-471 



toxicity, 391 

 p-Aminobenzoylglutamyl peptide, 490 

 7-Aminobutyric acid, formation of, 181 

 Amino sugars, 223 

 a-Amylase, 



dissociation of, 125 



inositol in, 10, 38, 106, 125 



occurrence, 126 

 Analogues of B vitamins, 443, 456-460 

 (See also individual vitamins) 



effect on coenzyme formation, 461 



pharmacological properties, 391 

 Androgens, 



inactivation of, 382 



role in nitrogen, phosphorus and potas- 

 sium retention, 381-382 

 Anemia, pernicious, 204, 415-417 



excretion of folic acid in, 571 



thymine in therapy of, 414 

 Anemias, 



associated with folic acid, vitamin Bi 2 

 deficiency, 413 



due to cobalt deficiency, 206 



"goat's milk," 419 



megaloblastic macrocytic, 419 



nutritional macrocytic, 419 



pregnancy macrocytic, 419 



tapeworm in macrocytic, 419-420 



"temporary pernicious," 419 

 Aneurin, 6 



Aneurin pyrophosphate, 164 

 Animal-protein factor, 14 

 Animals, 



absorption of B vitamins in, 343-345 



catabolism of B vitamins in, 351-370 



digestion in, 338-343 



Animals — Continued 



germ-free, 300 



synthesis of B vitamins in, 351-356 

 Annelida, B vitamin requirements of, 309 

 Anoxia, 



coenzyme breakdown in, 272 



effect on B vitamin requirements, 272 

 Antagonists, biochemical genetics in 



competitive, 477-478 

 Anthranilic acid, 287 

 Antibiotics, use in intestinal studies, 298 

 "Anti-dermatitis factor," 422 

 Anti-malarials, relation to riboflavin co- 

 enzymes, 679-681 

 Antipernicious anemia vitamin, 



absorption spectra, 206 



activity of nucleosides, 205 



activity of thymidine, 205 



as folic acid analogue, 290 



characterization of active compounds, 

 205 



coenzymatic role of, 112 



coenzymes, 206 



description, 14 



dosage, 14 



function, 14, 207, 474-475 



inhibition studies, 207 



interrelation to ascorbic acid, 204 



interrelation to folic acid, 206-207 



reactions catalyzed by, 206 



role in carbon to carbon bond forma- 

 tion, 189 



role in formation of serine and methi- 

 onine, 207 



role in utilization of PABA, 203, 207 

 Antipernicious anemia vitamin, defi- 

 ciency of, 



anemias associated with, 413 



pernicious anemia, 415-416 



sprue, 417-418 

 Anti-thiamine effects, 295 

 "Anti-thiamine enzyme," in raw fish, 155 

 "Anti-vitamins," use of, 260-261 

 Apocarboxylase, 157 

 Apoenzymes, 31, 109 



differential affinity for nicotinic acid 

 coenzymes, 118 

 Apoerythein, 415 

 Apophosphorylases, 134 

 APP, 154 

 Araboflavin, 296 

 Arecoline, 336, 389 

 Arginine, formation of, 181 

 Arthropoda, B vitamin requirements of, 



309 

 Ascorbic acid, 



distribution, 21-22 



effect on riboflavin storage, 258 



from carbohydrates, 223 



interrelation to carotenoids, 22 



interrelation to vitamin Bi 2 , 204 



oxidation-reduction potential effect, 21 



