INDEX 



727 



Aspartic acid, 



/3-alanine from, 85, 181 



function of biotin in synthesis of, 172 



interrelation to pantothenic acid, 466 

 Aspartic-alanine system, 182 

 Assay methods, (See also individual vita- 

 mins) 



biological, advantages of, 46 



chemical and physical-chemical, advan- 

 tages of, 45 



microbiological, advantages of, 46 



purposes, 45 

 Assays of urinary B vitamins, in humans, 



252, 254, 283 

 Atebrin, relation to riboflavin coenzymes, 



679-681 

 Auramine, 680 



Autoclaving, effect on pyridoxine, 176 

 Auximers, 316 



Auxin activity of vitamins, 316 

 Availability of B vitamins, 46, 283 

 Avidin, 12, 37, 559-561 



as egg white constituent, 294 



production in oviduct, 383 



properties of, 560 



Bacteria, 



B vitamin requirements of, 307 



intestinal, effect on B vitamin require- 

 ments, 297 



synthesis of B vitamins by, 299-300 

 Beriberi, 



analysis of diets, in 250-251 



historical, 398 



incidence, 398, 399 



infant, 399 



symptomology, 400-401 

 Betaine, 10 



Biochemical genetics, competitive antag- 

 onists and, 477-478 

 Biochemical reactions, 95 et seq. 



types of, 103 et seq. 

 Biocytin, 542 ff 

 Biological effects of B vitamins, 377 et 



seq. 

 Biological materials, B vitamin levels in, 



257-259 

 Biological oxidations and reductions (See 

 dehydrogenations) 



coenzymes mediating, 128 



mechanisms, 128 

 Biological potency of B vitamins, 283 

 Biological systems, energy transforma- 

 tions in, 100 

 Bioluminescence, 237-238 

 "Bios I," 710 



Biosynthesis of coenzymes, 112 

 Biotin, 



analogues, 289, 553-559 



as essential cell constituent, 174 



assay methods, 61-64 



bacterial production of, 87-88 



Biotin — Continued 



biochemical interrelationships, 467-468 



biosynthesis, 87-88 



coenzymes, 173 



combined forms, 37 



distribution, 23-24 



effect of potassium on deficiency, 249 



effect of species size on requirements 

 of, 321 



effect on pantothenate requirements, 

 278 



effect on root production, 88 



excretion, 87, 365-370 



extraction, 37 



functions, 170, 172 



hormone activity of, 337 



in deaminations, 172-173 



in synthesis of aspartic acid, 172 



in synthesis of oleic acid, 173 



inhibitory analogues, 553-559 



requirements, 326, 327, 329 



role in ^-decarboxylations, 154, 171 



sparing action of oleic acid on, 227 



specificity, 542-545 



stereoisomers, 542-544 



stimulatory analogues, 545-553 



structure, 8 



toxicity, 391 



"uncombinable," 62 

 Biotin deficiency, 



biochemical aspects of, 429 



in dogs, 249 



symptomology, 428 

 a-Biotin, 173 

 ^-Biotin, 173 

 Blacktongue, 412 

 Blood, 



B vitamin levels in, 345-347 



nicotinic acid content of, 258 

 Bound forms of B vitamins, 284 

 Bradycardia tests, 384 

 2,3-Butylene glycol, 222 



Cadaverine, formation of, 181 

 Caffeine, toxicity of, 297 

 Caloric intake, effect on B vitamin re- 

 quirements, 276 

 Cancer tissue, (See also tumors) 



B vitamin content, 27 



vitamin uniformity in, 27 



water content, 27 

 Carbohydrates, 



effect on B vitamin requirements, 276 



related compounds from, 223 



synthesis of fatty acids from, 222 



utilization of, 217 et seq. 

 Carbon to carbon bond formation, 106, 

 181 et seq. 



role of PABA in, 189 



role of thiamine in, 189 



role of vitamin Bi 2 in, 189 



