INDEX 



731 



Flavoproteins — Continued 

 L-amino acid oxidase, 32 

 comparison of reactions catalyzed by 

 to those of nicotinic acid system, 145 

 cytochrome-C reductase, 32 



diaphorases, 149 



in production of ethylenic bonds, 151 



intracellular forms, 147 



"old yellow enzyme," 32 



properties of, 145 



reaction types catalyzed by, 146 



redox properties of, 145 



types of, 147 



union with apoenzyme, 145 

 Flour, agenizing of, 297 

 Fluids, distribution and storage of B 



vitamins in, 350-351 

 Fluorescyanine, 285-286 

 Folic acid, 



p-aminobenzoic acid in activity of 

 xanthopterin, 421 



analogues, 290 



assay methods, 68-71 



biological activity of, 568-574 



biosynthesis, 88 



choline esterase, increase associated 

 with, 204 



combined forms, 39-40 



defective metabolism of tyrosine and, 

 204 



distribution, 40 



effect of related compounds on cancer, 

 593-597 



effect of species size on requirements 

 of, 322 



excretion, 365 



formyl derivative, 39 



functions, 488 



hematopoieses from, 202 



inhibitory analogues, 575-593 



in single carbon unit metabolism, 200 



isolation, 565 



liberation by enzymes, 40 



metabolism, 363 



oviduct response to stilbestrol and, 383 



pyridoxal-like activity of, 204-205 



relation to PABA, 202, 472, 490-493 



relation to pernicious anemia, 204 



relation to vitamin Bi 2 , 206 



relation to thymidine, 424 



requirements, 326, 327, 328, 329 



role in amino acid synthesis, 201 



role in erythropoiesis, 383 



role in purine and pyrimidine syn- 

 thesis, 202 



specificity, 566-568 



structure, 9, 493 



therapeutic use in pernicious anemia, 

 416 



toxicity, 390-391 

 Folic acid coenzymes, biosynthesis, 203 

 Folic acid deficiency, 413-422 



Folic acid deficiency — Continued 



anemias associated with, 413 



in vertebrates, 420 



in chicks, 248 



pernicious anemia and, 415, 416 



sprue, 417 

 Folinic acid, 16 ff, 203 ff 

 Foods, processing of, effect on B vitamin 



content, 282 

 "Formate carrying," coenzyme, 197 

 Formic acid, 



formation of, 197 



incorporation into purines, 196 



production from pyruvate, 162 

 Formic acid dehydrogenase, 152 

 Formylfolic acid, 39 



structure, 200 

 "Formyl group," 197 

 Formylpteroic acid, structure, 200, 422 

 Fowls, B vitamin requirements of, 259 

 Foxes, 



thiamin deficiency in, 292, 400 



Chastek paralysis, 292, 400 

 Free energy, prediction of reactions from, 



101 

 Fumaric acid, 



conversion to succinic acid, 151, 221 



formation, 221 

 Fumaric dehydrogenase, 150 

 Fumaric reductase, 221 

 Function of B vitamins in nutrition, 5 

 Function of B vitamins in metabolism, 



216 et seq. 

 Functional forms of B vitamins, 284 



Galvanic cell, action of, 129 

 Gametogenesis, B vitamins in, 383 

 Genetic blocks, partial, 217 

 Genetotrophic diseases, 433 

 Geriatrics, 266 



Germ-free animals, studies with, 300 

 Germination, B vitamin requirements 



for, 316 

 Glucose oxidase, 148 

 Glucose-6-phosphate, oxidation of, 136 

 Glutamic acid, 



as amino donor, 176 



in metabolism of PABA, 487-489 

 Glutamic-alanine system, 182 

 Glutamic-aspartic system, 182 

 Glutamic-aspartic transaminase, 187 

 Glutamic-cysteic acid system, 183 

 Glutathione, in function of glyoxalase, 



110 

 Glycerol, formation and utilization, 227- 



228 

 D-Glycerophosphate dehydrogenase, 152 

 Glycine, conversion to serine, 233 

 Glycine oxidase, 148 

 Glycogen, phosphorolysis of, 218-219 

 Glycolytic process, 



energy considerations, 218 



