INDEX 



733 



Inosital — -Continued 



stereoisomers, 711-712 



structure, 10, 711-712 



therapeutic use, 430 



toxicity, 391 

 Insects, 



B vitamin requirements of, 309-315 



effect of egg-white diets on, 314 



pyruvism in, 313 



symbiosis in, 309 



vitamin metabolism in, 314-315 

 Intake of B vitamins, recommended, 245 

 Intermediates, transport of labile, 121 

 "Intermediate carrier," 146 

 Interrelationships of B vitamins, 281-282, 

 379-380 



thiamine-vitamin A, 282 

 Intestinal flora, 264 



effect on B vitamin requirements, 297 

 Intestinal synthesis of B vitamins, 298 

 "Intrinsic factors," 206 

 Invertebrates, B vitamin requirements 



of, 306-315 

 Iodoacetate inhibition of thiamine phos- 

 phorylations, 155 

 Isoalloxazine, 143 



Isoalloxazine adenine dinucleotide, 143 

 Isomerases, 127 et seq. 

 Isomerization, in glycolysis, 219 

 Isotels, 173 

 Isotopic labeling, 102 

 Isoxanthopterin, 285 



Jackbean mean, crystalline urease from, 

 96 



Ketenyl radical, reactions of, 160 



a-Ketoglutaric acid, 

 as amino acceptor, 176 

 as source of single carbon unit, 197 

 decarboxylation by thiamine coen- 

 zyme, 158 

 reactions catalyzed by TPP, 167 

 role in synthesis of amino acids, 232 

 role of coenzyme in synthesis, 195 



Korsakoff's syndrome, 401 



Kwashiorkor, 407 



Kynurenin, 287 

 in synthesis of nicotinic acid, 83 



Labile intermediates, transport of, 121 

 Labor, effect on B vitamin requirements, 



267 

 Labor pains, thiamine in treatment of, 



356 

 Lactation, 



B vitamins and, 383 



effect on B vitamin requirements, 269 

 "Lactation factors," 383 

 Lactic acid dehydrogenase, 152 

 Lactobacillus bulgaricus factor, 16 ff 

 Lactochrome, 669 



Lactoflavin, 669 



Larvae, B vitamin requirements of, 311 



Lecithins, 39 



Leukemia, effect of folic acid analogues, 

 596 



Liberation of B vitamins, in intestinal 

 tract, 338 



"Light reaction," 238 



Linseed meal, anti-pyridoxine effect of, 

 295 



Lipides, metabolism of, 225, et seq. 



"Lipocaic," 127 



Lipositol, 38, 430 



Liver, inactivation of sex hormones by, 

 382 



Loading test, 255 



Lower forms of life, B vitamin deficien- 

 cies in, 397 



Luciferase, 238 



Luciferin, 238 



Lumazine, 285 



■Lumichrome, 363 



Lycomarasmine, 260, 296 



Lysine, relation to bacterial vitamin B a 

 requirements, 184 



Macrocytic anemias, 419-420 

 Magnesium ions, as cofactors for thi- 

 amine coenzyme, 158 

 Malic acid, formation of, 221 

 Malignant tissues, ratio of oxidized to 



reduced form of DPN in, 138 

 Mammals, B vitamin requirements of, 



329 

 Manioc, 296 

 Manganese ions, 



as cofactors for thiamine coenzyme, 

 158 



as cofactors in biotin enzymes, 171 

 Mass action effect in inhibition, 444 

 Maternal instinct, B vitamins and, 383 

 Mating behavior, B vitamins and, 383 

 Melanin production, 381 

 Menorrhagia, B vitamin treatment of, 



382 

 Mental activity, 



effect of B vitamins on, 385 



effect on B vitamin requirements, 267 

 Mental response, effect of thiamine on, 



385 

 Metabolic interrelationships of B vita- 

 mins, 379-380 

 Metabolic products, 



of nicotinic acid, 356-361 



of other B vitamins, 361-364 

 Metabolic rate, 264, 379 



effect of B vitamins on, 379 



effect on B vitamin requirements, 273 

 Metabolism, "total," 379 

 Metamorphosis, nutrition in, 309 

 Methionine, 10 



essential level, 279 



