734 



INDEX 



Methionine — Continued 



from homocysteine, 233, 234 



methyl groups from, 10, 234 



role of vitamin Bi» in formation, 207 

 Methyl groups, 



from choline, 10-11 



from methionine, 234 

 N'-methyl nicotinamide, 357 

 N'- methyl - 6 - py ridone -3- carboxy lamide, 



357 

 Metorrhagia, B vitamin treatment of, 



382 

 Mice, B vitamin requirements of, 327 

 Microbiological tests in discovery of B 



vitamins, 15 

 Milks, 



aldehyde oxidases in, 148 



B vitamins in, 20, 258, 347-350 



diaphorases from, 149 



pantothenate in, 85 



riboflavin in, 82, 271 



thiamine in, 271 



xanthine oxidase in, 148 

 "Mobile coenzymes," 137 

 Modification of B vitamins in intestinal 



tract, 337-338 

 Molds, riboflavin excretion in, 338 

 Monomethylethanolamine, 290 

 "Mouse anti-alopecia factor," 712 

 Muscle, 



diaphorases from, 149 



DPN from, 135 

 Muscular activity in B vitamin defi- 

 ciency, 399 

 Mycorrhizial fungi, 80-81 

 Myelin sheath, 384 



National Research Council, table of rec- 

 ommended dietary allowances for 

 humans, 324 

 Natural selection studies, 259-260 

 Nerve function, effect of B vitamins on, 



384 

 Nerve metabolism, role of vitamins in, 



384 

 Neuron, 384 

 Neurospora, 10 

 Niacin (see nicotinic acid) 

 Nicotinamide (see nicotinic acid) 

 Nicotine, 336, 389 



Nicotinic acid, (see also nicotinic acid- 

 type compounds) 

 activity of glutamic acid and aspara- 



gine, 84 

 analogues, 286 

 assay methods, 54-56 

 biological activity of, 604-611 

 biosynthesis, 82-83, 330, 353-356 

 combined forms, 33 

 content in blood, 259 

 distribution, 18 



Nicotinic acid — Continued 



effect of species size on requirement of, 

 320 



effect of tryptophan on requirement 

 of, 279 



excretion, 365 



extraction, 34 



inhibitory analogues, 280, 611-617 



interrelation to PABA, 282 



interrelation to pantothenic acid, 282 



lethal dosage, 389 



liberation by enzymes, 34 



natural antagonisms related to, 615-616 



pharmacological action, 387-388 



products of, 356-361 



replaceability by tryptophan, 279 



requirements, 317, 324, 326, 327, 328, 

 329 



specificity, 604, 611 



stimulatory action on plant roots, 82- 

 83 



structure, 7 



therapeutic use, 411 



toxicity, 387-388 

 Nicotinic acid coenzymes, (see also 

 DPN, TPN) 



absorption spectra, 134 



assay methods, 135 



biosynthesis, 138 



extraction, 137 



inactivation of, 134 

 Nicotinic acid deficiency, 408-412 



biochemical changes in, 412 



blacktongue, 412 



para-sprue, 410 



pellagra, 408-412 



symptomology, 409 

 Nicotinic acid type compounds, 



pharmacological action of, 388 



occurrence, 137 



oxidized and reduced forms, 133-134 



reactions catalyzed by, 139 et seq. 



redox systems coupled with, 140 



role in energy transformations, 140 



sources, 135 



specificity, 139 

 Nicotinuric acid, 287, 357 

 Nitrogen compounds, metabolism of, 230 



et seq. 

 Nitrogen retention, effect of androgens 



on, 381-382 

 Nitroid reaction, 387 

 "Norite-eluate factor," 69 

 Nucleosides, vitamin Bi 2 activity of, 205 

 Nucleotides, 7 



Nutrition, effect of sulfonamides on, 512 

 Nutritional customs, effect on B vitamin 



requirements, 202 

 Nutritional function of B vitamins, 5 

 "Nutritional requirement," 244 

 Nutritional status, 249 



