738 



INDEX 



Requirements for B vitamins — Cont'd 



effect of sex on, 266-267 



effect of shock on, 272 



effect of size on, 264 



effect of species size on, 319-323 



effect of surgery on, 272 



effect of thyroid on, 380-381 



effect of weight on, 266 



effect of work on, 267 



environment as factor, 264 



factors influencing, 264, et seq. 



growth as criterion for, 252 



maximal, 245 



methods of assessing, 243 



of aged, 266 



of arthropoda, 309-315 



of bacteria, 307 



of chicks, 327 



of children, 266 



of domestic birds, 328 



of fetuses, 270 



of fowls, 258 



of humans, 326 



of insects, 309-315 



of invertebrates, 306-315 



of mammals, 329 



of mice, 327 



of plant roots and embryos, 307 



of protozoa, 307 



of rats, 326 



of tissues, 259 



of vertebrates, 318-330 



of viruses, 307 



of worms, 308 



optimal, 245 



qualitative requirements, 244 



quantitative requirements, 245 



recommended intake, 245 



specie variability and, 264 



strain variability and, 265 

 Resection, effect on B vitamin require- 

 ments, 272 

 Resistance, mechanism in competitive in- 

 hibition, 475-477 



mechanism of sulfonamide, 519-520 



to sulfonamides, 516-521 

 Reversibility of a reaction, 101 

 Rhizopterin, 422, 566 



in folic acid assay, 70 



PABA in, 40 

 Riboflavin, 



analogues, 285-286 



assay methods, 51-56 



biological activity of, 670-673 



biosynthesis, 81-82 



combined forms, 32-33 



cooking and storage effect on, 33 



determination of, in serum, 259 



distribution of, 19 



effect of ascorbic acid on storage, 258 



effect of protein on requirement, 277 



Riboflavin — Continued 



effect of species size on requirement of, 

 319 



excretion, 271, 338, 365 



extraction, 33 



flavoproteins, 32 



function, in anaerobic systems, 150 



inhibitory analogues, 673-682 



in milk, 82 



metabolism of, 362 



"old yellow enzyme," 32 



requirements, 317, 324, 326, 327, 328, 

 329 



sparing effect of fatty acids on, 227 



specificity, 670-673 



stereoisomers, 671 



structure, 6 



toxicity, 390 

 Riboflavin coenzymes (see also flavopro- 

 teins) 



as hydrogen carriers, 141 



assay methods, 144 



biosynthesis, 144 



mechanism of oxidation and reduction, 

 146 



occurrence, 144 

 Riboflavin deficiency, 



biochemical changes in, 407-408 



distribution, 406 



symptomology, 406 

 Rice bran, crystalline thiamine from, 96 

 Rice moth larva, studies on, 311-312 

 Robinson ester, 136 

 Rous chicken sarcoma, 594-596 

 "Royal jelly," 22 

 Rumen, 



synthesis of pantothenic acid in, 85 



synthesis of riboflavin in, 82 



synthesis of thiamine in, 78-79 

 Ruminants, deficiency in young of, 298 



Sarcoma, 180, 597 



effect of folic acid on, 594-596 

 Sarcosine dehydrogenases, 152 

 "Saturation" with B vitamins, 370 

 Schiff's base formation, 186 

 Secondary products, effect in inhibition, 



461 

 Self-selection studies, 259-260 

 Serine, 



ethanolamine from, 181 



from glycine, 233 



role of vitamin Bis in formation of, 207 



trypotophan from, 183, 233 

 Sex, influence on B vitamin requirements, 



266-267 

 Sexual function, B vitamin deficiency 



and, 381-382 

 Shock, 



coenzyme breakdown in, 272 



effect on B vitamin requirements, 272 



