INDEX 



739 



Sickness, effect on B vitamin require- 

 ments, 271 

 Significance of distribution of B vita- 

 mins, 24-25 

 Silverfish, 315 

 Single carbon unit, 

 blocking of reactions by sulfonamides, 



200 

 coenzymes in utilization of, 196 et seq. 

 folic acid in, 200 

 in purines, 196 

 origin, 197 

 sources, 197 



vitamins associated with metabolism 

 of, 198 et seq. 

 Size, effect on B vitamin requirements of 



species, 319, 323 

 SLR factor, 200, 422 

 Sodium iodoacetate, inhibition of phos- 

 phorylation of thiamine, 156 

 Snake venom, 148 

 Solubility as criterion for classification of 



vitamins, 16 

 Solubility of B vitamins in water, 30 

 Sources of B vitamins, 30 et seq. 

 "Sparing effect" in inhibition studies, 



461 

 Specificity of B vitamins (see specific B 



vitamins) 

 Specificity of coenzymes, 115 

 Species, variability of, 264 

 Species size, relation of B vitamin re- 

 quirements to, 264, 319-323 

 Sphingomyelins, 39 

 Sprue, 417-418 

 symptomology, 417 

 therapy, 418 

 thymine in, 418 

 Standard potential, 131 

 Sterile animals, 

 studies with, 300 

 metabolism of, 228, 230 

 Sterility, B vitamin deficiency and, 381- 



382 

 Sterols, 

 role of Coenzyme A in synthesis of, 



195, 230 

 vitamins required in synthesis of, 230 

 Stilbestrol, effect on oviduct, 383 

 Storage of B vitamins, 255, 258-259 



in tissues and fluid, 350-351 

 Storage of foods, effect on riboflavin 



content, 33 

 Strain, variability of, 264 

 Strepogenin, 15, 260, 296, 397 

 Substrate, effect on rate of inhibited 



enzymatic reactions, 450 

 Succinic acid dehydrogenase, 152 

 Succinoxidase, 151 

 Sulfonamides, 

 activity in reversal with PABA, 496-499 



Sulfonamides — C ontimied 

 antagonism to chemotherapeutic ac- 

 tion, 498 

 antagonism to PABA of, 199, 494, 500 

 biological effects of, 511-516 

 blocking of single carbon unit metab- 

 olism by, 200 

 effect of ionization on activity, 501- 



502 

 effect of mass action on activity, 501 

 effect of pH on activity, 502-505 

 effect of physical properties on activity, 



501 

 effect of procaine on therapy with, 486 

 effect of resonance on activity, 510 

 effect of structure on activity, 501 

 effect of sulfonyl-negativity on activ- 

 ity, 505-509 

 effect on nutrition, 513 

 effect on respiration, 512 

 in inhibition analysis of PABA func- 

 tion, 470-471 

 inhibitions unaffected by PABA, 500 

 miscellaneous effects of, 515, 516 

 resistance to, 516-521 



Su If ones, 

 activity in reversal with PABA, 496- 



499 

 antagonism to PABA, 495 



Sulfonyl group, effect of negativity on 

 sulfonamides, 505-509 



Symbiosis, 

 in green plants, 79 

 in insects, 309 



Symbiotic microorganisms, 79 



Synergism, in inhibition, 463 



Synthesis of B vitamins in animals, 351 



Synthesis of coenzymes, 

 extent of, 113 

 rate of, 113 



Synthetic ability, impairment of, 217 



Taboos, effect on B vitamin requirement, 



282 

 Tapeworm, in anemia, 419-420 

 Temperature, effect on B vitamin re- 

 quirements, 267-268 

 Testosterone, effect of on excretion of 

 nitrogen, phosphorus, potassium, 381- 

 382 

 Thiaminase, 292-293 

 Thiamine, 



activating effect on carboxylase, 155 



analogues, 284-285, 688- 690 



antagonistic effects, 295 



as cofactor, 133 



assay methods, 47-51 



availability, from yeast, 291 



biological activity of, 687-694 



biosynthesis, 78-81 



cocarboxylase, 30 



combined forms, 30-31 



