740 



INDEX 



Thiamine — Continued 



content of diets of, 253 



curare-like action of, 386 



decline in urinary and tissue levels, 405 



distribution, 19 



-disulfide, 32 



effect of species size on requirement, 

 264, 319 



effect of yeast on dietary, 291 



effect on heart action, 384 



effect on mental activity, 385 



effect on nervous impulse, 384 



effect on plant and seedling growth, 80 



excretion, 271, 365 



extraction, 31 



functions, 168, 170 



inhibition of phosphorylation of, 155 



inhibitory analogues, 693-700 



interrelation to cholic acid, 282 



interrelation to vitamin A, 282 



lethal dosage, 386 



pharmacological action, 386 



-pyrophosphate, 154 



relation of structure to function, 167- 

 168 



requirements, 264, 317, 324, 326, 327, 

 328, 329 



sources, 30 



sparing effect, 276 



specificity, 684-694 



structure, 4 



therapeutic index, 386 



therapeutic use, 356, 381, 386 



toxicity of, 386-387 



variability in requirements of, 274 

 Thiamine coenzymes, 



assay methods, 155 



biosynthesis, 157 



formation of holoenzyme from, 157 



impermeability of cell membranes to, 

 158 



inhibition by thiamine, 157 



reactions catalyzed by, 158 et seq. 



role in carbon to carbon bond metab- 

 olism, 189 

 Thiamine deficiency, 



beriberi, 399-400 



biochemical features of, 403 



causes of, 399 



in foxes, 292, 402 



mild, 404 



nutritional polyneuritis, 400 



requirements to prevent, 264 

 Thiamine disulfide, thiamine activity of, 



168-169 

 Thiochrome, 685 

 Thiochrome method, 47-48 

 Thiochrome pyrophosphate, 155 

 Threonine, relation to pyridoxine require- 

 ment, 184 

 Thunberg technique, 149 



Thymidine, 15 



interrelation to antipernicious anemia 

 vitamin, 205 



interrelation to PABA and folic acid, 

 474 



structure, 15 

 Thymine, 290, 414 



in anemia therapy, 414, 416 



in sprue, 418 



structure, 414 

 Thyroid gland, 



effect on B vitamin metabolism, 381 



effect on B vitamin requirements, 380 

 Thysanura, 315 

 Ticks, 315 



"Tissue hunger," 254 

 Tissues, 



B vitamins in, 20, 258, 350-351 



B vitamins in human tissue, 26 



cancer, 27 



requirements for B vitamins of, 259 



"vitamin uniformity" in, 27 

 Tocopherols, distribution, 22 

 Toxicological level, 377 

 TPN, 133 



oxidation of reduced forms by cyto- 

 chrome-C-reductase, 150 

 TPP, synthetic preparation of, 154-155 

 Transaminases, 176 

 Transaminations, 176 

 Transesterifications, in glycolysis, 219 

 Transport of labile intermediates, 121 

 Tricarboxylic acid cycle, 223 

 Trigonellin, 83, 357 

 Triphosphopyridine nucleotide, 133 

 Tropical climate, effect on B vitamin re- 

 quirements, 267 

 Tryptophan, 83 



as substitute for nicotinic acid, 83, 

 279 



effect on excretion of niacin products, 

 83 



effect on niacin requirement, 279 



non-oxidative degradation, 183 



synthesis, 183, 233 

 Tumors, 26-27 



B vitamin content of, 28 



inhibition of proliferation of cells of, 

 203 



virus-induced, 28 

 Tyramine, formation of, 181 

 Tyrosine, defective metabolism of, 204 

 Tyrosine apodecarboxylase, 178 

 Tyrosine decarboxylase, 204 



Uncombinable biotin, 62-63 

 Unidentified factors in animal nutrition, 



244 

 Uniformity, coefficient of, 27 

 Uniformity of distribution of B vitamins, 



25 



