HYPOPHYSEAL MORPHOLOGY 



189 



Fig. 3.9 {npixr left). Section of the rat pais anterior showing the eaily response of the 

 thyrotrophs to thyroidectomy (6 days after thyroidectomy). The chister of large pale cells 

 is formed bv thyrotrophs which have degranulated but have not vet begun to hyalinize. PAS, 

 X 540. 



Fig. 3.10 (dipper right). Thyroidrctomy cells in the rat pars anterior 66 days after thyroid- 

 ectomy. Extensive accumulations (if li>;ihne substance distort the cells. Normal specific gran- 

 ulation is absent. The coarse, inteiisrly stained granules (T granules) are characteristic of pro- 

 longed thyroxine deficiency states. PAS, X 780. 



Fig. 3.11 (loiver left). Section of the rat pars anterior showing changes in follicle-stimulating 

 honuonc cells 10 wicks aft( i- laslration. The cells are numerous and large and a high propor- 

 I Kin lia\ r arciiiiiulaird hyahiir iiiaicrial to form "signet-ring" cells. There is an increase in the 

 i-diitciit (if granule- wliicli fdini cdarse, darkly stained clumps. PAS, X 580. 



Fi(i. 3.12 {lower right). Section of the rat pars anterior showing changes in luteinizing hor- 

 mone cells 16 weeks after castration. A proportion of the cells have accumulated hyaline ma- 

 terial and formed "signed-ring" cells. Both hyalinized and nonhyalinized cells show varying 

 intensities of staining indicating considerable variation in granule content in different cells. 

 There is often a higher content of granulation within the Golgi body than in the peripheral 

 cytoplasm. The characteristic difference between the appearances of the granulation in fol- 

 licle-stimulating hormone and luteinizing hormone cells is retained after castration. PAS, 

 X 580. 



large number of consistent differences be- 

 tween thyroidectomy and castration cells. 

 Morphologic differences were observed by 

 Hohlweg and Junkmann (1933), Zeckwer, 



Davison, Keller and Livingood (1935); 

 Zeckwer (1936, 1937, 1938a, b), and by 

 Giiyer and Clans (1935, 1937). A full ac- 

 count of the thvroidectomv and castration 



