402 



PHYSIOLOGY OF GONADS 



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I I'- <; II) 0.13. Rat ventr;il lu-o-tatc (Figs. 6 10. H.U) and coagulal iim aland ( Fm- C) 12, 

 (i.lo). All pliotomicrographs , lOUU. Fig. 6.10. 20-day cabtiatc. Fig. 6.11. 20-day ca.^tratf in- 

 jected with testis extract. Fig. 6.12. 20-day castrate. Fig. 6.13. 20-day castrate injected with 

 testis extract. (From C. R. Moore, D. Price and T. F. Gallagher, Am. J. Anat., 45, 71-107, 

 1930.) 



are prevented from collapsing by treatment 

 of castrates with testosterone and the proc- 

 ess is reversed if the androgen is given after 

 castration changes have developed (J. C. 

 Harkin, personal communication). Alka- 

 line and acid phosphatase levels are essen- 

 tially normal in castrates injected with 

 testost(M'one propionate (Stafford, Rubin- 

 stein and Meyer, 1949). 



Lateral prostate. The epithelial cells in 

 normal adult glands are columnar and the 

 nuclei are basal, but cell size and nuclear 

 position arc more variable than in the ven- 

 tral prostate ( Korenchevsky and Dcnnison. 

 193.51. The Golgi apparatus appears as 



l^rominent supranuclear networks in os- 

 mium stainecl preparations (Rixon and 

 Whitfield, 1959). 



Histochemical studies employing a di- 

 thizone zinc stain demonstrated high con- 

 centrations of zinc in the apical jiart of the 

 cells (Gunn and Gould, 19o6a). Fleisch- 

 hauer (1957) observed (macroscopically) 

 heavy staining that was visible in this lobe 

 after intravenous or subcutaneous injec- 

 tions of dithizone. In mifix(Hl frozen sections, 

 he found in tlic basal regions of all epi- 

 thelial cells numerous stained granules 

 which lie interpreted as zinc-positive ma- 

 terial. 'Hie nature of a rather wide diffusely 



