TABLE 8.1 

 Sequence of events in rabbit ovulation 



Time Post Coitum Central Nervous System 



Hypophysis 



Ovary 



Circulating Blood 



<30 sec. 



<2 mill. 



10 mill. 

 30 mill. 



60 mill. 



75-90 mill. 



13^-2 hrs. 

 3-5 hrs. 



6-7 hrs. 



7-8 hrs. 

 9-11 hrs. 



Barbiturate-sensi- 

 tive and atropine- 

 sensitive mecha- 

 nisms^ 



t Phosphorylation 

 in tuber cine- 

 reum^ 



t Phosphorylation 



in tuber ciner- 



reum- 

 t Phosphoryhition 



in tuber cine- 



reum^ 



t Phosphorylation 

 in tuber cine- 

 reum- 



t Phosphoryhition^ 



Release of LH ca. 

 20 per cent. 6 Hy- 

 pophysectomy 

 prevents ovula- 

 tion^' 12 



Release of LH now- 

 sufficient for ovul- 

 ation."' 12 Phos- 

 phorylation at 

 peak^ 



I Phosphor\iatioii 



i Animal may be bled 

 and transfused 

 without prevent - 



! ing ovulationi2 



folliculi. 

 in egg 



f Liquor 

 Tetrad.' 

 nuclei* 



Cholesterol deple- 

 tion in interstitial 

 gland. ^ Egg nu- 

 cleus migrates, 

 membrane dis- 

 solves.** • " Prom- 

 inent corona* 



Liquor folliculi in- 

 creasingly vis- 

 cous* 



First polar hotly'* 



Marked .swelling of 

 follicles. Thecal 

 hypertrophy,! ■ i° 

 hyperemia 



OvuL.^Tion." 

 t Phosphoryla- 

 tion2 



Bleeding and trans- 

 fusion now prevent 

 ovulationi2 



Progesterone detect- 

 able ^ 



Increased estrogen 

 (endometrial hj-- 

 peremia)' 



' Asdell, 1946. 



2 Borell, Westman and Orstrom, 1947. 



3 Claesson and Hillarp, 1947a. 

 " Fee and Parkes, 1929. 



'^ Forbes, 1953. 



« Hill, 1934. 



^ Sawyer, Markee and Hollinshcad, 1947. 



* Pincus and Enzmann, 1935. 



^ Sawyer and associates, 1947, 1949, 1950. 



1" Walton and Hammond, 192S. 



" Waterman, 1943. 



'2 Weslmaii and .lacohsohn, 1936. 



522 



