EDWARD C. ROSENOW 583 



from dental and other foci of infection of patients suffering from various diseases; 

 Bumpus and Meisser' have reported on cases of pyelonephritis and submucous ulcer 

 of the bladder and cystitis; and Meisser and Brock' on various forms of chronic 

 arthritis. Working with streptococci isolated from extirpated tonsils in cases of ulcer 

 of the stomach or duodenum, and of arthritis, Nakamura' obtained a much higher 

 incidence of lesions in these respective organs than following injection of strains from 

 tonsils in miscellaneous control cases. Giordano and Barnes^ proved the elective local- 

 izing power of streptococci isolated from pulpless teeth and systemic lesions after 

 death in cases of perforating ulcer, of gastric hemorrhage, and of perinephritic abscess. 

 Moench,5 through similar studies in animals, has shown that partial-tension strep- 

 tococci isolated from the cervix of patients suffering from endocervicitis and arthritis 

 have a marked affinity for the joints of animals. Brown^ has corroborated the work 

 on cholecystitis and ulcer of the stomach; and Rosenow and Ashby^ on myositis. 

 Cantero, in work as yet unpublished, noted similar results in ulcer of the stomach, 

 and he has applied my methods in a study of the etiology of goiter. He has found that 

 certain streptococci isolated from the thyroid in this disease tend to localize and pro- 

 duce lesions in the thyroid of animals. Bargen,^ by the use of the same methods, has 

 isolated a diplo-streptococcus from ulcers in the colon and from tonsils and teeth in 

 cases of chronic ulcerative colitis, which localizes electively in the colon of animals 

 and produces hemorrhages, ulcerations, and diarrhea. 



Gerdine and Helmholz,' by the use of similar methods, have shown that several 

 epidemics of duodenal ulcer in children were due to streptococci having peculiar 

 afi&nity for the duodenum. Kennedy'" has reported the finding of large numbers of 

 streptococci in small ulcers of the stomach and duodenum, the source of fatal intesti- 

 nal hemorrhage in cases of melena neonatorum. Helmholz and Beeler" have demon- 

 strated elective localizing power in strains of Bacillus coli and streptococci isolated 

 from cases of pyelonephritis in rabbits. Nickel, '" working with me in a long series of 

 experiments, has corroborated and extended the work on arthritis, on myocarditis 

 and endocarditis, on iritis, on ulcer of the stomach and duodenum, and on abortion. 



Especially noteworthy is the independent work by Haden. Not only has he ob- 

 tained comparable results in diseases such as ulcer of the stomach and duodenum,''^ and 



' Bumpus, H. C, Jr., and Meisser, J. G.: Arch. hit. Med., 27, 326. 1921; /. Urol., 5, 249. 1921. 



2 Meisser, J. G., and Brock, Sam: /. Am. Denl. A., 10, iioo. 1923. 



JNakamura, Tokukichi: Ann. Surg., 79, 29. 1924. 



■< Giordano, A. S., and Barnes, A. R.: /. Indiana M. A., 15, i. 1922. 



s Moench, L. Mary: /. Lab. &" Clin. Med., 9, 289. 1924. 



^ Brown, R. O.: Arch. Int. Med., 23, 185. 1919. 



' Rosenow, E. C, and Ashby, Winifred: ibid., 28, 274. 1921. 



^ Bargen, J. A.: J. A.M. A., 83, 332. 1924. 



'Gerdine, L., and Helmholz, H. F.: Am. J. Dis. Child., 10, 194. 1915. 



"Kennedy, R. L. J.: ibid., 31, 631. 1926. 



" Helmholz, H. F., and Beeler, Carol: /. Urol., 2, 395. 1918. 



"Nickel, A. C.: J.A.M.A., 87, 1117. 1926. 



■3 Haden, R. L.: Arch. Int. Med., 35,457. 1925. 



