EDWARD C. ROSENOW 



5^5 



The figures or statistical representation of the effects obtained in animal experi- 

 ments as shown in the tabulation, striking as they are, do not represent adequately 

 the observations at necropsy. The lesions produced in the corresponding organ fol- 

 lowing the injection of specific strains are often much more pronounced than are those 

 in these structures following the injection of strains from other sources. The value, 

 as given in the tabulation, of a small hemorrhage in or around one joint or of slightly 

 turbid joint fluid following injection of a strain from a case other than arthritis, is as 



TABLE I 



Localization in Animals of Streptococci from Patients Suffering 

 FROM Systemic Disease 



Source of Culturks 



Chronic arthritis 



Ulcer of stomach or duo 



denura 



Cholecystitis 



Myositis 



Neuritis 



Pyelonephritis 



Endocarditis 



Erythema nodosum 



Herpes zoster 



Diabetes 



Chorea 



Total 



Miscellaneous 



Animals 



41 



26 



12 



31 

 29 

 19 



337 

 129 



18 

 28 



13 

 II 



6 

 98 

 (29%) 

 39 



(30%) 



Results exclusive of specific strains . 



Cases 

 Yielding 

 Positive 

 Results 



15 



34 

 18 



95 



(78%) 



Percentage of Animals That De- 

 veloped Lesions In 



46,66 



71 



75,6: 



35 



29] 



14 



IS 



61 



65 



14 



50 



47 



48 



Cultures From 



^pecifir 

 Lesion 



No, 



42 



70 



67 



Blood 



No 



great as one or more greatly swollen joints with numerous hemorrhages containing 

 markedly turbid joint fluid, as commonly follows injection of a strain from cases of 

 arthritis. In a small percentage of animals the occurrence of lesions in organs besides 

 the one affected in the patient from whom the culture was obtained does not minimize 

 the significance of the results since certain patients present transient symptoms ref- 

 erable to other structures besides those chiefly and persistently affected. If the pa- 

 tient had symptoms of more than one disease, such as arthritis and cholecystitis, lo- 

 calization both in the joints and in the gall bladder sometimes occurred. 



The methods which have given so much useful information in the diseases studied 

 do not yield positive results in all diseases in which they have been applied. The re- 



