586 ELECTIVE LOCALIZATION OF BACTERIA 



suits in diabetes are merely suggestive, and thus far only negative results have been 

 obtained in pernicious anemia, in lymphatic and myelogenous leukemia, in hema- 

 turia, in certain lesions of the skin, in chronic diseases of the eye, and in catarrhal and 

 epidemic jaundice. 



ELECTIVE LOCALIZATION FOLLOWING INOCULATIONS OTHER THAN 

 J INTRAVENOUS INJECTION 



It must not be assumed that it is necessary to inject the bacteria intravenously 

 in order to produce lesions in the tissues for which they have elective localizing power. 

 Characteristic localization has been obtained repeatedly following other methods of 

 inoculation. Marked ulceration of the stomach in guinea pigs occurred following the 

 intraperitoneal injection of the streptococcus from a suppurative sinus draining the 

 infected tooth of a patient with acute ulcer of the stomach. Suppurative pulpitis and 

 hemorrhagic edema of the periosteum opposite the roots of the teeth of animals fol- 

 lowed the intraperitoneal injection of the streptococcus from the pulp of a tooth of a 

 patient who had recurring attacks of pulpitis, dental neuritis, and myositis. Locali- 

 zation in the alveolar epithelium of the lungs in guinea pigs occurred after intraperi- 

 toneal injection of a highly virulent, green-producing streptococcus from a case of 

 influenza. Suppurative endometritis was found often after intratracheal inoculation 

 of this organism freshly isolated from sputum or lung exudate in cases of severe pul- 

 monary influenza during the epidemic in 1918. Localization of streptococci, with 

 leukocytic infiltration, was found in the ileum following the intratracheal injection of 

 a small amount of hemorrhagic mucus containing streptococci from a patient with 

 intestinal influenza; hemorrhagic colitis developed after the injection into the stomach 

 of the freshly isolated streptococcus, in oil suspension, from another patient with in- 

 testinal influenza. 



The extreme specificity for muscles of a streptococcus from a case of myositis was 

 shown in an experiment in which the organism injected intravenously not only local- 

 ized in the muscles of a pregnant rabbit, but also in the corresponding muscles of the 

 fetuses. A streptococcus isolated from the tooth of a patient with recurring attacks 

 of iritis, myositis, and arthritis produced iritis, myositis, and arthritis on intravenous 

 injection, and also produced iritis, including the uninjected eye, and lesions in muscles 

 when extremely small doses were inoculated into the anterior chamber of one eye. 



A staphylococcus from an infected maxillary sinus and tonsils in a patient suffer- 

 ing from severe nephritis, and which localized electively in the kidney of rabbits on in- 

 travenous injection, produced nephritis when inoculated into devitalized teeth of 

 dogs.' Moreover, characteristic or other symptoms due to elective localization of strep- 

 tococci inoculated into the teeth of dogs have been reproduced by Rosenow and 

 Meisser^ in cases of nephrolithiasis, by Meisser^ in cases of ulcer of the stomach, and 

 by Rosenow in cases of chorea'^ and epidemic hiccup.^ The conditions around the teeth 

 in the dogs were similar to those following the devitalization of teeth in human den- 

 tistry. The infected teeth became discolored, but remained firmly in place in the 



' Rosenow, E. C, and Meisser, J. G.: /. Lab. 6* Clin. Med., 7, 707. 1922. 



* Rosenow, E. C, and Meisser, J. G.: Arch. Int. Med., 31, 807. 1923. 



3 Meisser, J. G.: /. Am. Dent. A., 12, 554. 1925. 



■f Rosenow, E. C.: Am. J. Dis. Child., 26, 223. 1923. 



5 Rosenow, E. C.: Arch. Neurol. £r Psychiat., 15, 712. 1926. 



