WILLIAM H. TALIAFERRO 



68i 



accumulation of the parasites, however, may be affected by one or both of two 

 entirely different mechanisms: first, the rate of reproduction of the parasites (cell 



ASEXUAL CYCLE 



Parasite''/ 

 Nucleus'' /' 

 PigiUQnt' 



SEXUAL 5TAGES:prGsenl at all hours 



Microgametocyles Macrogametocytejs 



Fig. 3. — -Representation of the cycle of reproduction in bird malaria showing changes in size. 

 Outlines of the asexual stages (X 1,500) of the parasites within the nucleated red cells, showing nuclei 

 and pigment granules, made at four-hour inter\-als during a consecutive period of twenty-four hours. 

 In addition, outlines of three microgametocytes and three macrogametocytes, which occur in small 

 numbers at all hours throughout the infection. (From drawings by L. G. Taliaferro.) 



division) may be retarded or inhibited; or, second, the parasites may be destroyed 

 after they are formed. Briefly, this may be expressed by an equation: 



(i) (2). (3) 



No. of parasites per cm. of blood = No. produced by reproduction — No. destroyed 



Hence, for any further analysis, the two mechanisms, represented by terms (2) and 

 (3), respectively, must be dift'erentiated. The methods devised to attain this end will 

 be outlined in the succeeding paragraphs. 



